孕期接种流行性感冒和新型冠状病毒疫苗安全性和有效性的研究进展  

Advances in research on the safety and efficacy of influenza and COVID-19 vaccination during pregnancy

作　　者：曾繁煜 蒋泓[1] 钱序[1] Zeng Fanyu;Jiang Hong;Qian Xu(School of Public Health,Fudan University(Key Laboratory of Health Technology Assessment,National Health Commission、Key Laboratory of Public Health Safety,Ministry of Education),Shanghai 200032,China)

机构地区：[1]复旦大学公共卫生学院(国家卫生健康委员会卫生技术评估重点实验室、公共卫生安全教育部重点实验室),上海200032

出　　处：《中华围产医学杂志》2025年第1期77-81,共5页Chinese Journal of Perinatal Medicine

基　　金：比尔和梅琳达·盖茨基金会项目(INV-034554);上海市加强公共卫生体系建设三年行动计划(2023-2025年)重点学科(GWⅥ-11.1-32)

摘　　要：孕期接种流行性感冒(简称流感)疫苗和新型冠状病毒疫苗(简称新冠疫苗)是预防感染的有效手段。孕期接种灭活流感疫苗是安全的。孕期接种灭活新冠疫苗对于妊娠期糖尿病和妊娠期高血压、新生儿低出生体重等母婴不良结局未有影响。孕期接种灭活流感疫苗和灭活新冠疫苗均有较好的保护效果。本文总结孕期流感疫苗和新冠疫苗接种的相关科学证据,为推动我国孕期疫苗接种相关实践提供科学依据。Maternal vaccination against influenza(commonly known as the flu)and the novel coronavirus(widely referred to as COVID-19)represents an effective strategy for infection prevention during pregnancy.The administration of inactivated flu vaccine during pregnancy is safe,and available evidence does not show adverse effects on maternal or neonatal outcomes such as gestational diabetes,gestational hypertension,or neonatal low birth weight.Both inactivated flu vaccines and inactivated COVID-19 vaccines have demonstrated protective efficacy when administered during pregnancy.This article summarizes the latest evidence on flu and COVID-19 vaccination during pregnancy,providing a scientific foundation to support vaccination practice during pregnancy in China.

关 键 词：流行性感冒疫苗 新型冠状病毒疫苗 孕期免疫 疫苗接种 疫苗安全性 疫苗有效性 

分 类 号：R715.3[医药卫生—妇产科学]