器官芯片技术在药物分析中的发展及应用  

Development and application of organ-on-chip technology in the field of drug analysis

作　　者：姜山 阚莹[2] 朱本峰 李红梅[2] 张炜飞 JIANG Shan;KAN Ying;ZHU Benfeng;LI Hongmei;ZHANG Weifei(College of Materials and Chemistry,China Jiliang University,Hangzhou 310018,China;Key Laboratory of Chemical Metrology and Applications on Nutrition and Health,State Administration for Market Regulation,Division of Chemical Metrology and Analytical Science,National Institute of Metrology,Beijing 100029,China)

机构地区：[1]中国计量大学材料与化学学院,杭州310018 [2]国家市场监督管理总局重点实验室(营养与健康化学计量及应用),中国计量科学研究院化学计量与分析科学研究所,北京100029

出　　处：《分析试验室》2025年第1期133-147,共15页Chinese Journal of Analysis Laboratory

基　　金：国家质量基础设施体系专项(2021YFF0600705);国家自然科学基金(22204155);中国计量科学研究院基本科研业务费项目(AKYKF2214)资助。

摘　　要：器官芯片是一项革命性的生物医学工程技术,作为一种高精度、高准确度的微生理系统,具有通量大、分析效率高、试剂消耗低、检测速度快、自动化程度高等优点,被认为是一种前景广阔的药物分析工具。本综述介绍了近几年器官芯片的发展进程,同时介绍了多个类型器官芯片在药物分析中的应用,包括肝芯片、肾芯片、脑芯片、肠芯片及多器官芯片。本综述同时总结了该领域所面临的一些关键挑战,并讨论了器官芯片在药物分析方面的发展前景,期望为利用器官芯片进行药物分析的研究提供有效的帮助和指导。Organ-on-chip(OoC)is a ground-breaking biomedical engineering technique.This high-precision and high-accuracy microphysiological system offers benefits including high throughput,high analytical efficiency,low reagent consumption,fast detection speed,and high degree of automation and is considered as a promising tool for drug analysis.This review details the developmental process of OoC in recent years,introduces the applications of various OoC,such as liver chips,kidney chips,brain chips,gut chips,and multi-organ chips,in drug analysis,summarizes the significant challenges faced,and discusses the prospects of OoC,offering useful assistance and guidance for drug analysis by OoC.

关 键 词：器官芯片 微生理系统 药物分析 

分 类 号：O657[理学—分析化学]