酉时加味交泰丸神阙穴敷贴治疗心肾不交型失眠临床疗效研究  

Study about the clinical effect of applying supplemented Jiaotai pills on RN8 in sunset on heart and kidney disharmony type of insomnia

作　　者：周洁[1] 穆雪峰 谭天林[1] 廖芳[1] 任思冲 童明欧[3] 唐晓英 嘉士健 谢小英[1] ZHOU Jie;MU Xuefeng;TAN Tianlin;LIAO Fang;REN Sichong;TONG Mingou;TANG Xiaoying;JIA Shijian;XIE Xiaoying(Xindu Hospital of Traditional Chinese Medicine,Chengdu,Sichuan 610500,China;Chengdu Medical College,Chengdu,Sichuan 610500,China;Sichuan Secend Hospital of Traditional Chinese Medicine,Chengdu,Sichuan 610000,China;Majia Community Healthcare Service of Banzhuyuan Town,Chengdu Xindu District,Chengdu,Sichuan 610500,China)

机构地区：[1]成都市新都区中医医院,四川成都610500 [2]成都医学院,四川成都610500 [3]四川省第二中医医院,四川成都610000 [4]成都市新都区斑竹园街道社区卫生服务中心马家分中心,四川成都610500

出　　处：《现代医药卫生》2025年第2期329-333,共5页Journal of Modern Medicine & Health

基　　金：四川省中医药科研专项课题(2020LC0056);成都市医学科研课题(2022463)。

摘　　要：目的分析自拟加味交泰丸神阙穴贴敷对心肾不交型失眠患者的影响。方法由成都市新都区中医医院制剂室加工加味交泰丸。招募心肾不交型失眠患者181例,将其分为酉时组、他时组、西药组,酉时组和他时组在神阙穴贴敷加味交泰丸,西药组口服艾司唑仑,15 d为1个疗程,共2个疗程。对比3组治疗1、2个疗程后匹兹堡睡眠质量指数量表(PSQI)评分、睡眠时间、有效率和自拟中医症候量表积分的变化。结果147例受试者完成第1个疗程试验,72例受试者完成第2个疗程试验。3组受试者进行15 d及30 d干预后,随着疗程增加,PSQI总分均值降低(Waldχ^(2)=16.602,P<0.001),睡眠时间不增加(Waldχ^(2)=0.131,P=0.718);不存在组别效应,不同干预方法对PSQI总分的减量差异无统计学意义(Waldχ^(2)=5.439,P=0.066),对睡眠时间的增量差异无统计学意义(Waldχ^(2)=2.749,P=0.253)。干预15 d后,3组自拟中医症候量表积分均下降(P<0.05),其中酉时组[17.00(15.00,21.00)分]与西药组[15.00(13.00,18.25)分]间差异有统计学意义(P=0.017)。干预15 d后,酉时组、他时组、西药组总有效率分别为76.2%、65.1%、64.5%,3组间有效率比较,差异无统计学意义(P=0.467)。结论自拟加味交泰丸神阙穴贴敷与艾司唑仑内服均能改善受试者的失眠;酉时贴敷与他时贴敷无差异;口服艾司唑仑也可改善失眠患者的心烦、眠差、多梦、耳鸣等伴随症状。Objective To investigate the clinical effect of applying supplemented Jiaotai pills on RN8 in sunset on heart and kidney disharmony type of insomnia.Methods Supplemented Jiaotai pills were processed by the preparation room of Xindu District Hospital of Traditional Chinese Medicine in Chengdu.A total of 181 insomnia patients suffering from heart and kidney disharmony type were recruited and randomly divided into Youshi group,Tashi group and western medicine group.The Youshi group and Tashi group were given Jiaotai pill at Shenq point,and the western medicine group was given esazolam orally,15 days for 1 course,a total of 2 courses.The changes of Pittsburgh Sleep Quality Index(PSQI)score,sleep time,effective rate and self-designed TCM symptom scale score after 1 and 2 treatment courses were compared in 3 groups.Results A total of 147 subjects completed the first course and 72 subjects completed the second course.After 15 days and 30 days of intervention,with the increase of treatment duration,the total mean PSQI decreased(Waldχ^(2)=16.602,P<0.001),sleep duration did not increase(Waldχ^(2)=0.131,P=0.718);there was no group effect,and there was no significant difference in the reduction of PSQI total score(Waldχ^(2)=5.439,P=0.066)and no significant difference in the increment of sleep time(Waldχ^(2)=2.749,P=0.253)between three groups.After 15 days of intervention,the scores of self-designed TCM syndrome scale of the 3 groups all decreased(P<0.05),and there was a statistically significant difference between the control group[17.00(15.00,21.00)]and the Estazolam group[15.00(13.00,18.25)](P=0.017).After 15 days of intervention,the total effective rate of Youshi group,Tashi group and western medicine group was 76.2%,65.1%and 64.5%,respectively,and there was no statistical difference between three groups(P=0.467).Conclusion Applying supplemented Jiaotai pills on RN8 and oral Esazolam both could relieve heart and kidney disharmony type of insomnia of patient.There is no difference between Youyang group and Tashi group;

关 键 词：交泰丸 中药制剂 失眠 心肾不交 穴位贴敷 神阙穴 

分 类 号：R256.23[医药卫生—中医内科学]