川芎嗪注射液联合丁苯酞对急性缺血性脑卒中患者的影响  

Effect of Ligustrazine Injection Combined with Butylphthalein on Patients with Acute Ischemic Stroke

作　　者：敬乃鲁 JING Nailu(Department of Neurology,Lanling People’s Hospital,Linyi 276000,China)

机构地区：[1]山东省兰陵县人民医院神经内科,山东临沂276000

出　　处：《中国伤残医学》2024年第21期84-87,92,共5页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:探讨川芎嗪注射液联合丁苯酞对急性缺血性脑卒中(AIS)患者的影响。方法:回顾性分析2020年12月—2023年4月兰陵县人民医院收治的70例AIS患者临床资料,根据治疗方法不同将其分为对照组和研究组,各35例。对照组采用丁苯酞治疗,研究组采用川芎嗪注射液联合丁苯酞治疗。治疗2周后,对比两组神经功能、血流动力学指标、凝血指标、生活质量和不良反应发生情况。结果:治疗后,两组美国国立卫生研究院卒中量表评分均低于治疗前,且研究组比对照组低,世界卫生组织生存质量测定量表各维度评分均高于治疗前,且研究组均比对照组高,差异均有统计学意义(P<0.05)。治疗后,两组大脑动脉收缩期峰值血流速均快于治疗前,且研究组比对照组快,两组搏动指数及阻力指数均低于治疗前,且研究组均比对照组低,差异均有统计学意义(P<0.05)。治疗后,两组活化部分凝血活酶时间、凝血酶原时间均高于治疗前,且研究组均比对照组高,两组纤维蛋白原均低于治疗前,且研究组均比对照组低,差异均有统计学意义(P<0.05)。研究组不良反应发生率为14.29%,高于对照组的8.57%,但差异无统计学意义(P>0.05)。结论:川芎嗪注射液联合丁苯酞治疗AIS患者,能够有效改善血流动力学及凝血指标,加速患者神经功能的恢复,提升生活质量,且具备较好的安全性。Objective:To investigate the effects of Ligustrazine Injection combined with Butylphthalein on patients with acute ischemic stroke(AIS).Methods:Clinical data of 70 AIS patients admitted to Lanling People’s Hospital from December 2020 to April 2023 were retrospectively analyzed,and were divided into a control group and a study group according to different treatment methods,with 35 cases in each group.The control group was treated with Butylphthalein,and the study group was treated with Butylphthalein combined with Ligustrazine Injection.After 2 weeks of treatment,neurological function,hemodynamic index,coagulation index,quality of life and adverse reactions were compared between the two groups.Results:After treatment,the scores of the National Institutes of Health Stroke Scale in both groups were lower than before treatment,and the study group was lower than the control group,and the scores of the World Health Organization Quality of Life scale in all dimensions were higher than before treatment,and the study group was higher than the control group,with statistical significance(P<0.05).After treatment,the peak blood flow velocity of cerebral artery systole in both groups was higher than before treatment,and the study group was higher than the control group,the pulsation index and resistance index in both groups were lower than before treatment,and the study group was lower than the control group,the differences were statistically significant(P<0.05).After treatment,the activated partial thromboplastin time and prothrombin time in both groups were higher than before treatment,and the study group was higher than the control group,and the fibrinogen in both groups was lower than before treatment,and the study group was lower than the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the study group was 14.29%,which was higher than 8.57%in the control group,but the difference was not statistically significant(P>0.05).Conclusion:Ligustrazine Injection combined

关 键 词：急性缺血性脑卒中 川芎嗪注射液 丁苯酞 血清炎性因子 血液流变学 

分 类 号：R543[医药卫生—心血管疾病]