基于“引经理论”探讨中药调控SDF-1/CXCR4信号通路影响骨髓间充质干细胞归巢及分化的科学内涵  

Scientific connotation of regulating SDF-1/CXCR4 signaling pathway by traditional Chinese medicine in bone marrow mesenchymal stem cell homing and osteogenic differentiation based on meridian guide theory

作　　者：孙钰 刘恩旭 李兆勇 杨少锋[2] SUN Yu;LIU Enxu;LI Zhaoyong;YANG Shaofeng(Hunan University of Chinese Medicine,Changsha 410208,China;The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410007,China)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]湖南中医药大学第一附属医院,湖南长沙410007

出　　处：《中草药》2024年第20期7172-7179,共8页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(82174402);湖南省自然科学基金项目(2023JJ60345,2023JJ60342);湖南省教育厅科学研究项目(21C0233);湖南省卫健委科研计划项目(202204074858);湖南省博士研究生科研创新课题项目(CX20220807)

摘　　要：“引经理论”为中医基础理论的重要内容与“归经理论”同源发展。骨髓间充质干细胞(bone mesenchymal stem cells,BMSCs)广泛分布于骨髓及各种结缔组织中,具有极强的多向分化、自我复制与自我更新能力。基质细胞衍生因子-1 (stromal cell-derived factor-1,SDF-1)/CXC型趋化因子受体4 (C-X-C motif chemokine receptor 4,CXCR4)信号通路为目前学界公认的影响BMSCs归巢及分化的热点通路。基于SDF-1/CXCR4信号通路,以BMSCs归巢及分化为切入点,将中医“引经理论”与细胞靶向迁移学说相结合、使宏观中医理论具体化,进而从分子生物学角度深入探讨中医“引经理论”的科学性与可行性,为引经药物靶向干预BMSCs的临床应用提供充分的理论依据。Meridian guide theory is an important element of the basic theory of traditional Chinese medicine(TCM),which is homologous to the theory of attribution of meridians.Bone marrow mesenchymal stem cells(BMSCs)are widely distributed in bone marrow and various connective tissues,and have strong multi-directional differentiation,self-replication and self-renewal abilities,and the SDF-1/CXCR4 signaling pathway is currently recognised as a hotspot signaling pathway that affects the homing and differentiation of BMSCs.Based on the SDF-1/CXCR4 signaling pathway,this paper takes BMSCs homing and differentiation as an entry point,and combines the TCM meridian guide theory with cell-targeted migration theory to make the macroscopic TCM theory concrete,and then discusses the scientific validity and feasibility of TCM meridian guide theory in depth from the perspective of molecular biology.We also discussed the scientific validity and feasibility of the TCM meridian guide theory from the perspective of molecular biology,and provided sufficient theoretical basis for the application of meridian-inducing drug-targeting intervention in BMSCs.

关 键 词：引经理论 骨髓间充质干细胞 SDF-1/CXCR4 细胞归巢及分化 细胞靶向迁移学说 

分 类 号：R285[医药卫生—中药学]