姜黄素拮抗重金属镉、铅毒性机制的研究进展  

Research progress on antagonistic mechanism of curcumin against heavy metal cadmium and lead toxicity

作　　者：高汶静 梅雪婷[2] 郑西雨 彭俊伟 麦智聪 许东晖 GAO Wenjing;MEI Xueting;ZHENG Xiyu;PENG Junwei;MAI Zhicong;XU Donghui(Chinese Medicine and Marine Laboratory,School of Life Sciences,Sun Yat-sen University,Guangzhou 510275,China;Laboratory Animal Center,Sun Yat-Sen University,Guangzhou 510080,China)

机构地区：[1]中山大学生命科学学院中药与海洋药物实验室,广东广州510275 [2]中山大学实验动物中心,广东广州510080

出　　处：《中草药》2024年第20期7132-7143,共12页Chinese Traditional and Herbal Drugs

基　　金：广州市科技计划项目(202201011656)

摘　　要：随着工业城市化扩大,重金属镉、铅排放失当可能造成环境污染。流行病调查发现镉、铅积累与代谢性疾病、肿瘤、神经毒性等高发密切相关,造成体内锌稳态失衡、脂联素表达异常。目前抗重金属中毒的螯合剂、化疗药物均无法调节锌稳态失衡。姜黄素是来自姜黄Curcumae Longae Rhizoma的天然多酚类物质,具有抗氧化、抗肿瘤、抗炎症等药理作用。其结构上具有酮-烯醇互换的结构,可络合镉、铅离子,具有降低镉、铅毒性的开发价值。通过对近年来国内外姜黄素及姜黄素-锌拮抗重金属镉、铅毒性作用机制进行阐述,以期针对镉、铅导致的多种疾病提供有效的防控手段。With the expansion of industrial urbanization,improper discharge of heavy metals cadmium and lead has caused environmental pollution.Epidemiological investigations have found that cadmium and lead accumulation is closely related to the high incidence of metabolic diseases,tumors and neurotoxicity,resulting in an imbalance of zinc homeostasis in the body and abnormal expression of adiponectin.The current chelating agents and chemotherapeutic drugs against heavy metal poisoning are unable to regulate zinc homeostatic imbalance.Curcumin is a natural polyphenol from Jianghuang(Curcumae Longae Rhizoma)with pharmacological effects such as antioxidant,antitumor and anti-inflammatory.Its structure has a keto-enol interchangeable structure,which can complex cadmium and lead ions and has the development value of reducing cadmium and lead toxicity.In this paper,the mechanism of antagonism of heavy metal cadmium and lead toxicity by curcumin and curcumin-zinc complexes at home and abroad in recent years is elaborated to provide effective means of prevention and control for a variety of diseases caused by cadmium and lead.

关 键 词：姜黄素 镉 铅 锌稳态 重金属毒性 

分 类 号：R285.5[医药卫生—中药学]