斑马鱼心血管疾病模型的建立及中药干预作用研究进展  

Research progress on establishment of zebrafish cardiovascular disease model and intervention effect of traditional Chinese medicine

作　　者：李嘉欣 白立鼎 李琳[1,2] 王炎炎[1] 王婷[1] 潘桂湘[1] 李玉红[1,2] LI Jiaxin;BAI Liding;LI Lin;WANG Yanyan;WANG Ting;PAN Guixiang;LI Yuhong(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;State Key Laboratory of Component-based Chinese Medicine,Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学,天津301617 [2]天津中医药大学中医药研究院组分中药国家重点实验室,天津301617

出　　处：《中草药》2024年第20期7122-7131,共10页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(82204867);国家自然科学基金资助项目(82404901);天津中医药大学新教师科研启动项目(XJS2022209)

摘　　要：斑马鱼作为一种新型的模式动物,具有易饲养、繁殖发育迅速、实验周期短、与人类基因有高度同源性等特点。中药治疗心血管疾病(cardiovasculardisease,CVD)具有疗效好、活性强、不良反应小的优点,但由于其有效成分复杂、作用机制和靶点多样,斑马鱼胚胎透明便于观察、心脏功能易于量化,在CVD的研究中取得了很大进展。通过对心肌损伤、脂质异常、心力衰竭、血栓等疾病中斑马鱼模型的研究进展及其中药的干预作用进行综述,总结了运用斑马鱼模型评价中药心脏毒性的应用进展,及斑马鱼模型在研究血管新生和淋巴管新生中的应用。Zebrafish,as a new model animal,has the characteristics of easy breeding,rapid reproduction and development,short experimental period,and high homology with human genes.Traditional Chinese medicine(TCM)has the advantages of good efficacy,strong activity and small adverse reactions in treatment of cardiovascular disease(CVD).However,due to its complex effective ingredients,various mechanisms of action and targets,zebrafish embryos are transparent and easy to observe,and heart function is easy to quantify,have made great progress in the study of CVD.This paper reviews the research progress of zebrafish model and the intervention effect of TCM in myocardial injury,lipid abnormality,heart failure,thrombosis and other diseases,summarizes the application progress of zebrafish model in evaluating the cardiotoxicity of TCM,and the application of zebrafish model in studying angiogenesis and lymphangiogenesis.

关 键 词：斑马鱼模型 心血管疾病 心脏毒性 血管新生 淋巴管新生 心肌损伤 脂质异常 心力衰竭 

分 类 号：R285[医药卫生—中药学]