质子泵抑制剂与胃黏膜保护剂治疗咽喉反流性疾病临床疗效及安全性对比的Meta分析  

Meta-analysis of the clinical efficacy and safety of proton pump inhibitors versus gastric mucosal protective agents in the treatment of laryngopharyngeal reflux disease

作　　者：米雪芹 李松哲 邓英杰 李圣洋 肖丁齐 樊磊 MI Xueqin;LI Songzhe;DENG Yingjie;LI Shengyang;XIAO Dingqi;FAN Lei(Department of Otorhinolaryngology&Head and Neck Surgery,Chengdu Sixth People̓s Hospital,Chengdu 610051,Sichuan,China;College of Sports Medicine and Rehabilitation,North Sichuan Medical College,Nanchong 637000,Sichuan,China)

机构地区：[1]成都市第六人民医院耳鼻咽喉头颈外科,四川成都610051 [2]川北医学院运动医学与康复学院,四川南充637000

出　　处：《山东大学耳鼻喉眼学报》2024年第6期136-142,共7页Journal of Otolaryngology and Ophthalmology of Shandong University

基　　金：南充市社会科学研究“十四五”规划2024年度项目(NC24C150)

摘　　要：目的 利用Meta分析的方法分析质子泵抑制剂(proton pump inhibitors, PPIs)与胃黏膜保护剂治疗咽喉反流性疾病(laryngopharygeal reflux disease, LPRD)的临床疗效和安全性。方法 用计算机检索知网、万方、维普、CBM、PubMed、Embase、Cochrane library、Web of Science中英文数据库,搜集有关PPIs、胃黏膜保护剂与LPRD相关的研究,时间范围为建库起至2024年9月。由两名独立评价者筛选文献、提取资料,并用R4.3.1软件对符合质量标准的研究进行Meta分析。结果 最终纳入了6项随机对照试验(randomized controlled trials, RCT),Meta分析结果显示PPIs治疗LPRD有效率优于使用胃黏膜保护剂[RR=1.19(95%CI:1.10~1.29,P<0.001)];PPIs治疗LPRD不良反应发生率较使用胃黏膜保护剂差异无统计学意义[RR=0.51(95%CI:0.18~1.41,P=0.19)];差异均有统计学意义。结论 在LPRD疗程不超过4周的短期治疗中,PPIs较胃黏膜保护剂能显著提高临床疗效,但其不良反应的发生率与胃黏膜保护剂无明显差异。Objective To analyse the clinical effectiveness and safety of proton pump inhibitors(PPIs)and gastric mucosal protec-tors in the treatment of laryngopharygeal reflux disease(LPRD)by Meta-analysis.Methods The CNKI,Wanfang,VIP,CBM,PubMed,Embase,Cochrane library,Web of Science databases on PPIs,gastric mucosal protectors and LPRD were retrieved up to September 2024.Two reviewers screened the literature,extracted data and performed meta-analysis of studies that met the quality criteria using R4.3.1 software.Results Six randomised controlled trials(RCT)were included,and the results of the meta-analysis showed that the response rate of LPRD with PPIs was better than that of gastric mucosal protectors[RR=1.19(95%CI:1.10-1.29,P<0.0001)];the incidence of adverse reactions of PPI treatment in LPRD was not significantly different from that of gastric muco-sal protectors[RR=0.51(95%CI:0.18-1.41,P=0.19)];the differences were statistically significant.Conclusion In short-term treatment with an LPRD course of no more than 4 weeks,PPIs significantly improved clinical efficacy compared with gastric muco-sal protectors,but the incidence of adverse effects was not significantly different from that of gastric mucosal protectors.

关 键 词：质子泵抑制剂 胃黏膜保护剂 咽喉反流性疾病 META分析 

分 类 号：R766.5[医药卫生—耳鼻咽喉科] R573.9[医药卫生—临床医学]