咽喉反流性疾病的内镜下治疗  

Endoscopic treatment of laryngopharyngeal reflux disease

作　　者：席晓宇 隋昕珂[1] 陈升 李连勇[1] 钟长青 XI Xiaoyu;SUI Xinke;CHEN Sheng;LI Lianyong;ZHONG Changqing(Department of Gastroenterology,the Ninth Medical Centerof Chinses PLA General Hospital,Beijing 100101,China)

机构地区：[1]中国人民解放军总医院第九医学中心消化内科,北京100101

出　　处：《山东大学耳鼻喉眼学报》2024年第6期61-65,共5页Journal of Otolaryngology and Ophthalmology of Shandong University

基　　金：战略支援部队特色医学中心博士毕业生科研启动基金(21ZX11)

摘　　要：咽喉反流性疾病(laryngopharyngeal reflux disease, LPRD)是指胃十二指肠内容物反流至食管上括约肌以上的上呼吸消化道,包括鼻咽、口咽、咽喉和喉等部位,可引起上呼吸消化道的形态学改变及一系列症状和体征的总称,治疗一直以来以质子泵抑制剂为主导,部分药物治疗效果不佳或对药物治疗不耐受的患者,可考虑抗反流手术治疗。手术方式既往以腹腔镜胃底折叠术为主要方式,随着消化内镜技术的发展,逐步出现多种内镜下的抗反流新技术,它们具有住院天数短、症状评分下降明显、并发症少、经济等优势,如内镜下抗反流黏膜切除术、射频消融术、经口无切口胃底折叠术等,成为越来越多患者的选择,论文对内镜抗反流手术治疗LPRD进行综合叙述。Laryngopharyngeal reflux disease denotes the comprehensive manifestation of gastrointestinal contents refluxing to the re-gion above the esophageal sphincter,eliciting a spectrum of symptoms and signs.Treatment has traditionally relied on proton pump inhibitors as the primary intervention,while laparoscopic fundoplication stands as the predominant surgical modality.With the con-tinuous evolution of digestive endoscopy technology,a myriad of novel endoscopic techniques have emerged.These techniques con-fer advantages such as reduced hospitalization duration,marked alleviation in symptomatology,diminished incidence of complica-tions,and favorable cost-effectiveness.Illustrative examples encompass endoscopic mucosal resection for anti-reflux,radiofrequency ablation,and transoral incisionless fundoplication.This manuscript offers a comprehensive exposition of such endoscopic modalities.

关 键 词：咽喉反流性疾病 内镜下经口无切口胃底折叠术 抗反流黏膜切除术 射频消融术 内镜吻合器胃底折叠术 

分 类 号：R766.5[医药卫生—耳鼻咽喉科]