血清腱糖蛋白C与过氧化物酶体增殖物激活受体γ共激活因子-1α及高迁移率族蛋白B1水平联合检测对慢性左心衰竭患者预后的预测价值  

Predictive value of serum tenascin-C,peroxisome proliferator activated receptor-γcoactivator-1α,high mobility group box-1 protein levels in patients with chronic left heart failure

作　　者：曹迎迎 崔梦珂 白丹[1] CAO Ying-ying;CUI Meng-ke;BAI Dan(Cardiovascular Intensive Care Unit,the 7th People's Hospital of Zhengzhou,Henan 450000,China;不详)

机构地区：[1]郑州市第七人民医院心血管重症监护室,河南450000

出　　处：《慢性病学杂志》2024年第10期1471-1474,共4页Chronic Pathematology Journal

基　　金：河南省医学科技攻关联合共建项目(LHGJ20220836)

摘　　要：目的分析血清腱糖蛋白C(tenascin-C,TN-C)、过氧化物酶体增殖物激活受体γ共激活因子-1α(peroxisome proliferator-activated receptor-γcoactivator-1α,PGC-1α)、高迁移率族蛋白B1(high mobility group box-1 protein,HMGB1)水平联合检测对慢性左心衰竭患者预后的预测价值。方法选取2022年5月—2023年12月郑州市第七人民医院诊治的慢性左心衰竭患者设为研究组(n=82),根据1∶1比例,另选取同期的健康体检者设为对照组(n=82)。对比两组入院时的血清TN-C、PGC-1α、HMGB1水平;对比不同预后患者的血清TN-C、PGC-1α、HMGB1水平;偏回归分析血清TN-C、PGC-1α、HMGB1水平与患者预后的关联性并分析入院时血清TN-C、PGC-1α、HMGB1水平联合检测对慢性左心衰竭患者预后的预测价值。结果入院时,研究组的血清TN-C、HMGB1水平均高于对照组(t=14.428、19.648,均P<0.05),血清PGC-1α低于对照组(t=13.885,P<0.05);入院时,预后不良患者的血清TN-C、HMGB1水平均高于预后良好患者(t=11.325、7.217,均P<0.05),血清PGC-1α低于预后良好患者(t=9.631,P<0.05);logistic回归分析显示,入院时,血清TN-C(OR:2.994,95%CI:1.392~6.441)、HMGB1(OR:2.677,95%CI:1.137~6.304)为患者发生预后不良的危险因素,血清PGC-1α(OR:0.414,95%CI:0.194~0.882)为患者发生预后不良的保护因素(均P<0.05);入院时,血清TN-C、PGC-1α、HMGB1水平联合预测患者发生预后不良的价值均高于各指标单独预测(AUC:0.909,P<0.05)。结论血清TN-C、PGC-1α、HMGB1水平变化与患者预后相关,联合检测对患者发生预后不良具有更佳的预测效能。Objective To analyze the predictive value of combined detection of the levels of serum tenascin-c(TN-C)and peroxisome proliferator-activated receptor-γcoactivator-1α(PGC-1α)and high mobility group box-1 protein(HMGB1)in the prognosis of patients with chronic left heart failure.Methods Patients with chronic left heart failure in the 7th People's Hospital of Zhengzhou from May 2022 to December 2023 were selected as the study group(n=82),and according to the ratio of 1:1,healthy medical checkups in the same period of time were also selected as the control group(n=82).The levels of serum TN-C,PGC-1αand HMGB1 at admission were compared between the two groups;the serum levels of TN-C,PGC-1αand HMGB1 in patients with different prognosis were compared;partial regression analysis was used to analyze the correlation between the serum levels of TN-C,PGC-1αand HMGB1 and the prognosis of patients,and the predictive value of serum levels of TN-C,PGC-1αand HMGB1 on the prognosis of patients with chronic left heart failure was analyzed.Results On admission,the serum levels of TN-C and HMGB 1 in the study group were higher than those in the control group(t=14.428,19.648,all P<0.05),serum PGC-1αwas lower than the control group(t=13.885,P<0.05);on admission,serum TN-C and HMGB 1 levels were higher in patients with poor prognosis than in patients with good prognosis(t=11.325,7.217,all P<0.05),serum PGC-1αwas lower than in patients with good prognosis(t=9.631,P<0.05);By logistic regression analysis,on admission,serum TN-C(OR:2.994,95%CI:1.392-6.441),HMGB1(OR:2.677,95%CI:1.137-6.304)as a risk factor for developing a poor prognosis in patients,serum PGC-1α(OR:0.414,95%CI:0.194-0.882)was a protective factor for the poor prognosis of patients(all P<0.05);on admission,the combination of serum TN-C,PGC-1αand HMGB 1 predicted worse prognosis in patients than each index alone(AUC:0.909,P<0.05).Conclusion Changes in serum TN-C,PGC-1α,and HMGB 1 levels were correlated with patient prognosis,and better predictive efficacy in combine

关 键 词：左心衰竭 预后 炎症介质 

分 类 号：R541.61[医药卫生—心血管疾病] R47[医药卫生—内科学]