Basiliximab is superior to low dose rabbit anti-thymocyte globulin in pediatric kidney transplant recipients:The younger,the better  

作　　者：Lan Zhu Lei Zhang Wenjun Shang Wenhua Liu Rula Sa Zhiliang Guo Longshan Liu Jinghong Tan Hengxi Zhang Yonghua Feng Wenyu Zhao Wenqi Cong Jianyong Wu Changxi Wang Gang Chen 

机构地区：[1]Institute of Organ Transplantation,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Key Laboratory of Organ Transplantation,Ministry of Education,NHC Key Laboratory of Organ Transplantation,Key Laboratory of Organ Transplantation,Chinese Academy of Medical Sciences,Wuhan,Hubei 430030,China [2]Department of Organ Transplantation,First Affiliated Hospital,Naval Medical University,Shanghai 200443,China [3]Department of Renal Transplantation,First Affiliated Hospital,Zhengzhou University,Zhengzhou,Henan 450052,China [4]Clinical Research Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China [5]Organ Transplant Center,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong 510080,China [6]Center of Nephrology,First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,Zhejiang 310003,China

出　　处：《Chinese Medical Journal》2025年第2期225-227,共3页中华医学杂志(英文版)

基　　金：supported by the Clinical Research Flagship Project of Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology(No.2019CR108).

摘　　要：To the Editor:To reduce the risk of acute rejection(AR)after renal transplantation,immunosuppressive induction therapy has been commonly used in the perioperative period.At present,rabbit anti-thymocyte globulin(rATG)and basiliximab are the two main induction agents used for kidney transplantation.In adult kidney transplantation,the incidence of AR with rATG induction is generally lower than that with basiliximab.[1]Children have different immune systems than adults do.In pediatric kidney transplantation,which induction therapy is more effective in preventing early AR is an important clinical question worth answering.Because there are few reports in this field and differences in the immune systems of children at different ages,we have now conducted a total and age-stratified analysis of Chinese multicenter cohort data to compare the AR rates and other outcomes between rATG and basiliximab induction therapy groups in pediatric deceased-donor kidney transplantation.

关 键 词：acute rejection ar immunosuppressive induction therapy pediatric kidney transplantation rabbit anti thymocyte globulin kidney transplantationthe BASILIXIMAB induction agents 

分 类 号：R726.9[医药卫生—儿科]