抗甲状腺过氧化物酶抗体及甲状腺球蛋白抗体与非毒性结节性甲状腺肿术后复发的相关性研究  

Correlation study between anti-thyroid peroxidase antibody,thyroglobulin antibody and postoperative recurrence of nontoxic nodular goiter

作　　者：李东方 何康伯 谭亦好 蒋晓松[2] 林高[2] LI Dong-fang;HE Kang-bo;TAN Yi-hao;JIANG Xiao-song;LIN Gao(Deparment of General Surgery,Qiao li Hospital of Traditional Chinese Medicine of Doumen District(Doumen Hospital of Guangdong Province Hospital of Traditional Chinese Medicine),Zhuhai,Guangdong 519125,China;不详)

机构地区：[1]珠海市斗门区侨立中医院(广东省中医院斗门医院)外一科,广东519125 [2]广东省中医院珠海医院外一科

出　　处：《慢性病学杂志》2024年第11期1625-1628,共4页Chronic Pathematology Journal

基　　金：2022年珠海市社会发展领域科技计划项目(2220004000313)

摘　　要：目的探究抗甲状腺过氧化物酶抗体(thyroid peroxidase antibody,TpoAb)、甲状腺球蛋白抗体(thyroglobulin antibody,TgAb)与非毒性结节性甲状腺肿(nontoxic thyroid nodular goiter,NTNG)术后复发的相关性。方法选取2014年1月—2020年12月珠海市斗门区侨立中医院、广东省中医院珠海医院收治并行手术的600例非毒性结节性甲状腺肿患者为研究对象,根据术后血清TpoAb和TgAb水平分为4组,A组189例(TpoAb<60.00 U/mL,TgAb<60.00 U/mL),B组157例(TpoAb<60.00 U/mL,TgAb≥60.00 U/mL),C组163例(TpoAb≥60.00 U/mL,TgAb<60.00 U/mL),D组91例(TpoAb≥60.00 U/mL,TgAb≥60.00 U/mL)。比较各组患者术后2年的复发率,并分析各组的临床病理特征(性别、年龄、甲状腺结节是否多发等)。结果A组复发13例(6.88%),B组复发22例(14.01%),C组复发20例(12.27%),D组复发32例(35.16%)。D组、C组、B组复发率均高于A组,且D组高于C组、B组,差异有统计学意义(χ^(2)=40.885,P<0.001);各组的甲状腺结节多发(χ^(2)=33.434)和白细胞介素-17(interleukin,IL-17)水平(F=7.833)比较,差异均有统计学意义(均P<0.05)。结论TpoAb、TgAb异常表达可增加非毒性结节性甲状腺肿术后的复发风险,且其与甲状腺结节多发及IL-17水平关系密切。Objective To investigate the thyroid peroxidase antibody(TpoAb)and thyroglobulin antibody(TgAb)and postoperative recurrence of nontoxic thyroid nodular goiter(NTNG).Methods 600 patients with nontoxic thyroid nodular goiter treated and operated in Qiaoli Hospital of Traditional Chinese Medicine of Zhuhai Doumen and Guangdong Province Hospital of Traditional Chinese Medicine(Zhuhai Hospital)from January 2014 to December 2020 were selected as the study subjects.According to postoperative serum TpoAb and TgAb levels,they were divided into four groups:There were 189 cases in group A(TpoAb<60.00 U/mL,TgAb<60.00 U/mL),157 cases in group B(TpoAb<60.00 U/mL,TgAb≥60.00 U/mL),163 cases in group C(TpoAb≥60.00 U/mL,TgAb<60.00 U/mL),and 91 cases in group D(TpoAb≥60.00 U/mL,TgAb≥60.00 U/mL).The recurrence rate 2 years after surgery was compared among all groups,and the clinicopathological characteristics(gender,age,multiple thyroid nodules,et al.)were compared among all groups.Results There were 13 patients in Group A(6.88%),22 in Group B(14.01%),20 in Group C(12.27%),and 32(35.16%)in Group D.Group D,C and B recurrence rate were all higher than Group A,and Group D was higher than Group C and B(χ^(2)=40.885,P<0.05);more thyroid nodules(χ^(2)=33.434)and IL-17 levels(F=7.833),respectively(all P<0.05).Conclusion Abnormal expression of TpoAb and TgAb may increase the risk of postoperative recurrence of nontoxic nodular goiter,which is closely related to multiple thyroid nodules and IL-17 level.

关 键 词：非毒性结节性甲状腺肿 甲状腺过氧化物酶抗体 甲状腺球蛋白抗体 术后复发 相关性 

分 类 号：R653[医药卫生—外科学]