宫颈炎患者解脲支原体感染状况及药敏性分析  

Analysis of Ureaplasma Urealyticum Infection Status and Drug Sensitivity in Cervicitis Patients

作　　者：谢孟颖 葛卫卫 Xie Mengying;Ge Weiwei(Department of Laboratory Medicine,Luohe Third People’s Hospital,Luohe,Henan,462300,China)

机构地区：[1]漯河市第三人民医院检验科,河南漯河462300

出　　处：《黑龙江医学》2025年第4期469-471,共3页Heilongjiang Medical Journal

摘　　要：目的:分析宫颈炎患者解脲支原体(UU)感染状况及药敏性,为临床合理选用治疗药物提供参考。方法:回顾性分析2022年1月-2023年3月漯河市第三人民医院收治的120例宫颈炎患者作为研究对象,采集宫颈处分泌物并检测UU感染情况。依据是否感染UU分为阳性组、阴性组,比较其宫颈黏液炎性因子水平[白细胞介素-6 (IL-6)、C反应蛋白(CRP)],采用Spearman法分析炎性因子与UU感染相关性。采用体外药敏实验分析UU感染对应的耐药性情况。结果:120例宫颈炎患者共检出UU感染率为25.00%(30/120);31~40岁女性、工人或农民、初中及以下宫颈炎患者中UU感染率较高;阳性组IL-6、CRP水平高于阴性组,差异均有统计学意义(t=30.676,9.352,P<0.05);UU感染与IL-6、CRP呈正相关,差异均有统计学意义(r=0.396,0.507,P<0.05);UU对美满霉素、强力霉素、红霉素、克拉霉素的敏感度较高,而对甲砜霉素、罗红霉素、阿奇霉素、左氧氟沙星表现为耐药。结论:宫颈炎患者UU感染率较高,主要分布于31~40岁女性、工人或农民、初中及以下女性,UU对美满霉素、强力霉素、红霉素、克拉霉素敏感,可选取其作为首选治疗药物。Objective:To analyze the infection status and drug sensitivity of ureaplasma Urealyticum(UU)in patients with cervicitis,and to provide reference for rational selection of therapeutic drugs in clinic.Methods:120 cases of cervicitis treated in the hospital from January,2022 to March,2023 were retrospectively selected as the study objects.Cervical secretions were collected and UU infection was detected.They were divided into positive group and negative group according to whether they were infected with UU,and their cervical mucus inflammatory factor levels[interleukin-6(IL-6),C-reactive protein(CRP)]were compared.The correlation between inflammatory factors and UU infection was analyzed by Spearman method.The drug resistance corresponding to UU infection was analyzed by in vitro drug sensitivity test.Results:UU infection rate was 25.00%(30/120)in 120 patients with cervicitis.UU infection rate was higher in women aged 31~40,workers or farmers,junior high school and below cervicitis patients.The levels of IL-6 and CRP in the positive group were higher than those in the negative group(t=30.676,9.352;P<0.05).UU infection was positively correlated with IL-6 and CRP(r=0.396,0.507;P<0.05).UU has a high sensitivity to minocycline,doxycycline,erythromycin,and clarithromycin,but is resistant to thiamphenicol,roxithromycin,azithromycin,and levofloxacin.Conclusion:Patients with cervicitis have a high UU infection rate,mainly distributed among women aged 31~40,workers or farmers,and women with junior high school or lower education.UU is sensitive to minocycline,doxycycline,erythromycin and clarithromycin,which can be selected as the first-line treatment drug.

关 键 词：宫颈炎 解脲支原体 感染 药敏性 相关性 

分 类 号：R711.74[医药卫生—妇产科学]