可注射水凝胶在治疗心肌梗死中的研究进展  

Research progress of injectable hydrogels in the treatment of myocardial infarction

作　　者：王亚澜 郑雯文 谢艳兰 刘佳杰 吕明珠 张家燕[2] 雍媛 WANG Yalan;ZHENG Wenwen;XIE Yanlan;LIU Jiajie;LÜMingzhu;ZHANG Jiayan;YONG Yuan(School of Chemistry and Environment,Southwest Minzu University,Chengdu 610041,China;Department of Pediatrics,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China;School of Chemistry and Materials Science,Sichuan Normal University,Chengdu 610066,China)

机构地区：[1]西南民族大学化学与环境学院,四川成都610041 [2]川北医学院附属医院儿科,四川南充637000 [3]四川师范大学化学与材料科学学院,四川成都610066

出　　处：《西南民族大学学报(自然科学版)》2025年第1期57-64,共8页Journal of Southwest Minzu University(Natural Science Edition)

基　　金：国家自然科学基金面上项目(52273304);四川省自然科学基金杰出青年科学基金项目(25NSFJQ0088);中国科协青年人才托举工程((YESS)2022-2024QNRC002);西南民族大学“维舟团队”专项资金项目(SMUWZ202414);川北医学院附属医院科研发展计划重点项目(2023-2ZD004);智能纳米水凝胶用于儿童特应性皮炎治疗及其机制研究项目(2024PTZK001)。

摘　　要：心肌梗死会触发不良的心室重构,从而导致心力衰竭,对人类的生命健康造成了严重的威胁,目前的临床治疗方法在预防心肌梗死后不良心肌重塑和增强机电耦合方面的效果有限,往往导致临床预后不佳,不能有效改善心肌梗死微环境.目前,基于生物材料的支架应用成为提供机械支持和促进细胞生长的可行方法,可注射水凝胶通过微创注射给药和降低感染风险,在心肌梗死治疗中获得了大量的关注.因此,为了充分了解可注射水凝胶和梗死心肌修复之间的相互作用,结合可注射水凝胶在治疗心肌梗死中的优势和潜能,概括了可注射水凝胶的主要类型,简述了可注射水凝胶在治疗心肌梗死中的应用.最后总结和展望了可注射水凝胶在生物医学领域面临的挑战和发展前景.Myocardial infarction triggers adverse ventricular remodeling,which leads to heart failure and poses a serious threat to human life and health.Current clinical therapies have limited effectiveness in preventing adverse myocardial remodeling and enhancing electromechanical coupling after myocardial infarction,often leading to poor clinical prognosis and failing to effectively improve the myocardial infarction microenvironment.Currently,biomaterial-based scaffold applications are emerging as a viable way to provide mechanical support and promote cell growth,and injectable hydrogels have gained a great deal of attention in myocardial infarction therapy through minimally invasive injection drug delivery and reduced risk of infection.Therefore,in order to fully understand the interaction between injectable hydrogels and infarcted myocardial repair,this paper outlined the main types of injectable hydrogels and briefly described the application of injectable hydrogels in the treatment of myocardial infarction,taking into account the advantages and potential of injectable hydrogels in the treatment of myocardial infarction.Finally,it concluded and looked forward to the challenges and development prospects of injectable hydrogels in the biomedical field.

关 键 词：可注射水凝胶 心肌梗死微环境 生物材料 机械支持 梗死心肌修复 

分 类 号：R542.2[医药卫生—心血管疾病] TQ427.26[医药卫生—内科学]