基于3D打印和静电纺丝制备双层结构的腹壁补片  

Preparation of Double-layer Abdominal Wall Patch Based on 3D Printing and Electrospinning

作　　者：胡庆夕[1] 张宇 张海光[1] HU Qingxi;ZHANG Yu;ZHANG Haiguang

机构地区：[1]上海大学机电工程与自动化学院快速制造中心

出　　处：《计量与测试技术》2025年第1期131-134,共4页Metrology & Measurement Technique

基　　金：国家自然科学基金项目(项目名称:大块关节骨软骨多细胞再生支架构建和多工艺耦合的成形机理及试验研究,项目编号:52175474;项目名称:含载细胞微球的无机/有机双相活性大块仿生骨支架一体化成形机理与试验研究,项目编号:52275498)。

摘　　要：腹壁缺损是常见的腹壁外科疾病,通常是将腹壁补片植入体内进行修复。本文基于3D打印和静电纺丝,制备双层结构的腹壁补片,并对其表面形态、机械强度、亲水性、抑菌性、细胞毒性和细胞黏附性能进行测试。结果表明:该补片的机械性能、亲水性和抑菌性均符合修复需求,且无细胞毒性,防粘层具有较好的防细胞黏附的效果。Abdominal wall defect is a common surgical disease of the abdominal wall,which is usually repaired by inserting abdominal wall patches into the body.In this paper,a double-layer abdominal wall patch was prepared based on 3D printing and electrospinning,and its surface morphology,mechanical strength,hydrophilicity,bacteriostasis,cytotoxicity and cell adhesion properties were tested.The results showed that the mechanical properties,hydrophilicity and bacteriostasis of the patch met the requirements of repair,and there was no cytotoxicity.The anti-adhesion layer had a good effect of preventing cell adhesion.

关 键 词：3D打印 静电纺丝 腹壁补片 抑菌性能 防粘性能 

分 类 号：TP391.73[自动化与计算机技术—计算机应用技术] R318.08[自动化与计算机技术—计算机科学与技术] R656.3[医药卫生—生物医学工程]