血清甲状腺激素FT3、FT4和TSH水平在精神分裂症患者中的表达及意义  

Expression and Significance of Serum Thyroid Hormone FT3,FT4 and TSH Levels in Patients with Schizophrenia

作　　者：蓝丽香 上官晓萍 罗锦林 谢晓兰 何泉芳 Lan Lixiang;Shangguan Xiaoping;Luo Jinlin(Medical Laboratory,The Third Hospital of Longyan City,Longyan,Fujian,364000,China)

机构地区：[1]龙岩市第三医院医学检验实验室,福建龙岩364000 [2]龙岩市第三医院精神医学科,福建龙岩364000 [3]龙岩市第三医院药剂科,福建龙岩364000 [4]厦门医学院附属龙岩人民医院,福建龙岩364000

出　　处：《黑龙江医学》2025年第3期312-315,共4页Heilongjiang Medical Journal

基　　金：福建省龙岩市科技计划项目(2022LYF17005)。

摘　　要：目的:分析精神分裂症患者血清甲状腺激素[游离三碘甲状原氨酸(FT3)、游离甲状腺素(FT4)和促甲状腺激素(TSH)]表达水平及意义。方法:纳入2021年7月—2023年5月龙岩市第三医院收治的240例精神分裂症患者和240例经检查未患精神疾病者作为研究对象,分别设为观察组和对照组,两组受试者均进行血清甲状腺激素水平测定,应用受试者工作特征(ROC)曲线分析血清甲状腺激素诊断精神分裂症的效能,同时应用修改版外显攻击行为量表(MOAS)对观察组暴力行为进行评价,对比有无暴力行为的精神分裂症患者的血清甲状腺激素水平,应用Spearman法分析血清甲状腺激素与精神分裂症患者暴力行为的相关性。结果:观察组患者FT3、FT4和TSH高于对照组,差异均有统计学意义(t=11.490、11.881、15.663,P<0.05)。FT3、FT4和TSH等血清甲状腺激素指标诊断精神分裂症的效能良好,差异有统计学意义(P<0.05)。有暴力行为精神分裂症患者的FT3、FT4和TSH高于无暴力行为精神分裂症患者,差异均有统计学意义(t=5.328、4.233、5.612,P<0.05)。结论:FT3、FT4和TSH血清甲状腺激素在精神分裂症患者中呈高水平表达,且有暴力行为的患者FT3、FT4和TSH血清甲状腺激素水平均高于无暴力行为,可见FT3、FT4和TSH血清甲状腺激素在精神分裂症诊断和暴力行为风险评估方面提供了有效客观依据。Objective:To analyze the expression levels and significance of serum thyroid hormones[free triiodothyronine(FT3),free thyroxine(FT4)and thyroid-stimulating hormone(TSH)]in patients with schizophrenia.Methods:A total of 240 patients with schizophrenia and 240 patients without mental illness admitted to the hospital from July 2021 to May 2023 were enrolled in the observation group and control group,respectively.Serum thyroid hormone levels of both groups were measured.The efficacy of serum thyroid hormone in the diagnosis of schizophrenia was analyzed by receiver operating characteristic(ROC)curve.The violent behavior of the observation group was evaluated by modified Explicit Aggressive Behavior Scale(MOAS).The serum thyroid hormone levels in schizophrenic patients with or without violent behavior were compared.And the correlation between serum thyroid hormone and violent behavior in schizophrenic patients was analyzed by Spearman method.Results:FT3,FT4 and TSH in the observation group were higher than those in the control group(t=11.490,11.881,15.663;P<0.05).Serum thyroid hormone markers,such as FT3,FT4 and TSH etc.,had good efficacy in diagnosing schizophrenia(P<0.05).FT3,FT4 and TSH of patients with violent schizophrenia were higher than those of patients with non-violent schizophrenia(t=5.328,4.233,5.612;P<0.05).Conclusion:Serum thyroid hormones,such as FT3,FT4 and TSH,are expressed at a high level in patients with schizophrenia,and the serum thyroid hormones levels of FT3,FT4 and TSH in patients with violent behavior are higher than those in patients without violent behavior,indicating that serum thyroid hormones,such as FT3,FT4 and TSH,provide an effective and objective basis for the diagnosis of schizophrenia and the risk assessment of violent behavior.

关 键 词：精神分裂症 游离三碘甲状原氨酸 游离甲状腺素 促甲状腺激素 修改版外显攻击行为量表 

分 类 号：R322.51[医药卫生—人体解剖和组织胚胎学]