注射用卡络磺钠联合氨甲环酸对股骨颈骨折患者围术期失血及纤溶指标、炎症因子的影响  

Effects of Carbazochrome Sodium Sulfonate for Injection Combined with Tranexamic Acid on Perioperative Blood Loss,Coagulation Indexes and Inflammatory Factors in Patients with Femoral Neck Fracture

作　　者：钟建元 高晓乐 ZHONG Jian-yuan;GAO Xiao-le(Department of Orthopedics,Fujian Medical University Union Hospital,Fuzhou,350000,China;Department of Trauma surgery,Fuzhou Second General Hospital,Fuzhou,350007,China)

机构地区：[1]福建医科大学附属协和医院骨科,福州350000 [2]福州市第二总医院创伤骨科,福州350007

出　　处：《神经药理学报》2024年第6期45-49,共5页Acta Neuropharmacologica

基　　金：福建省卫生健康科技计划项目(No.2023QNA097)。

摘　　要：目的:探讨注射用卡络磺钠联合氨甲环酸对股骨颈骨折患者围术期失血的影响。方法:福建医科大学附属协和医院接受手术治疗的股骨颈骨折患者120例随机分为对照组与观察组各60例。于切皮前5 min,两组均予以氨甲环酸1 g静脉滴注,手术结束即刻,观察组予以注射用卡络磺钠静脉滴注,对照组则予以生理盐水静脉滴注。记录两组围术期失血情况,于术前及术后1 d,检测患者外周血对纤维蛋白原降解产物(fibrin degradation products,FDP)、D二聚体水平,并检测血清白细胞介素-6(interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)水平,记录两组术后住院时间和并发症情况。结果:较对照组,观察组总失血量和隐性失血量均减少(P<0.05),术后引流量、最大血红蛋白(hemoglobin,Hb)下降值和异体输血均显著下降(P<0.05)。术后1 d,两组FDP、D-二聚体、IL-6、CRP水平均上升(P<0.05),但相比对照组,观察组FDP、D-二聚体、IL-6、CRP水平较低(P<0.05)。较对照组,观察组术后住院时间更短(P<0.05),两组感染、下肢肌间静脉血栓形成发生率差异无统计学意义(P>0.05)。结论:注射用卡络磺钠联合氨甲环酸使用能够减少股骨颈骨折患者围术期失血,抑制纤溶,减轻炎症,缩短术后住院时间,且不增加并发症。Objective:To investigate the effect of carbazochrome sodium sulfonate for injection combined with tranexamic acid on perioperative blood loss in patients with femoral neck fracture.Methods:A total of 120 patients with femoral neck fracture undergoing surgical treatment were randomly divided into control group and observation group,with 60 cases in each group.Five minutes before skin incision,both groups were given intravenous infusion of tranexamic acid 1 g.Immediately after the operation,the observation group was given intravenous infusion of carbazochrome sodium sulfonate for injection,while the control group was given intravenous infusion of normal saline.The perioperative blood loss of the two groups was recorded.The levels of fibrinogen degradation product(FDP)and D-dimer in peripheral blood of the patients were detected before and 1 day after operation,and the levels of serum interleukin-6(IL-6)and C-reactive protein(CRP)were detected.The postoperative hospitalization time and complications of the two groups were recorded.Results:Compared with the control group,the total blood loss and hidden blood loss in the observation group were decreased(P<0.05),and the postoperative drainage volume,maximum Hb decrease value and allogeneic blood transfusion were significantly decreased(P<0.05).One day after operation,the levels of FDP,D-dimer,IL-6 and CRP in the two groups increased(P<0.05),but compared with the control group,the levels of FDP,D-dimer,IL-6 and CRP in the observation group were lower(P<0.05).Compared with the control group,the postoperative hospital stay in the observation group was shorter(P<0.05).There was no significant difference in the incidence of infection and lower extremity intermuscular venous thrombosis between the two groups(P>0.05).Conclusion:The use of carbazochrome sodium sulfonate for injection combined with tranexamic acid can reduce perioperative blood loss,inhibit fibrinolysis,reduce inflammation,shorten postoperative hospital stay,and do not increase complications in patients with fe

关 键 词：股骨颈骨折 围术期失血 氨甲环酸 注射用卡络磺钠 炎症 

分 类 号：R969[医药卫生—药理学]