中国少数民族MN血型分布  

Distribution of MN blood type among China’s minority ethnic groups

作　　者：王文文 陈萍[2] 宋奥微 王文华[2] 牛佳萌 邢莉莉 杨江存[2] 孙杨[2] 张超 WANG Wenwen;CHEN Ping;SONG Aowei;WANG Wenhua;NIU Jiameng;XING Lili;YANG Jiangcun;SUN Yang;ZHANG Chao(Laboratory Department of Xuyi Hospital,Xianyang 711300;Blood Transfusion Department,Shaanxi Provincial People’s Hospital,Xi’an 710068;Business Department,Hanzhong Central Blood Station,Hanzhong 723000,China)

机构地区：[1]旬邑县医院检验科,陕西咸阳711300 [2]陕西省人民医院输血科,陕西西安710068 [3]汉中市中心血站业务科,陕西汉中723000

出　　处：《细胞与分子免疫学杂志》2025年第1期51-56,共6页Chinese Journal of Cellular and Molecular Immunology

基　　金：陕西省人民医院领军人才项目(2021LJ-14)。

摘　　要：目的调查分析中国少数民族MN血型的分布情况。方法通过系统检索MN血型分布相关文献981篇,筛选出数据完整且符合本研究标准的文献120篇,涵盖49个少数民族。采用SPSS26统计软件对数据进行分析。结果中国49个少数民族的MN血型表型分布为MN>MM>NN,其占比分别42.54%、41.86%、15.06%。MN血型基因频率表现为m>n,m=0.6313,n=0.3687。通过聚类分析,中国49个少数民族的m基因频率分为3簇,呈现Ⅰ簇>Ⅱ簇>Ⅲ簇的特征。结论中国少数民族MN血型特征表现为m基因频率高于n基因频率;南方少数民族m基因频率高于北方民族;西南少数民族m基因频率与汉族存在显著差异,与汉族长期杂/聚居的少数民族无差异。Objective This study aims to investigate and analyze the distribution of MN blood type among ethnic minorities in China.Methods Through a systematic retrieval of the 981 literature related to MN blood group distribution,120 literature,meeting the criteria of this study,with complete data were selected.The literature covers 49 ethnic minorities.SPSS 26 statistical software was used to analyze the data.Results The results showed that among the 49 ethnic minorities in China,the phenotype distribution of MN blood type was MN>MM>NN,with proportions of 42.54%,41.86%,and 15.06%respectively.The gene frequency for MN blood type exhibited a trend of m>n,with a gene frequency of m being 0.6313 and n being 0.3687.Cluster analysis divided the Chinese ethnic minorities into three groups based on the gene frequency for m,showing the characteristics of GroupⅠ>GroupⅡ>GroupⅢ.Conclusion The MN blood type characteristics in Chinese ethnic minorities show a higher frequency of the M gene compared to the N gene.The frequency of the M gene is higher in southern ethnic minorities than in northern ones.There are significant differences between southwestern ethnic minorities and the Han nationality,but no differences with long-term mixed/settled Han populations.

关 键 词：MN血型 少数民族 基因频率 

分 类 号：R457.11[医药卫生—治疗学]