代谢生物钟:昼夜节律调控代谢研究的最新进展  

Circadian Metabolism:What's new in circadian regulation of metabolism

作　　者：李旻典 张舰心 LI Mindian;ZHANG Jianxin(Department of Cardiovascular Diseases,Center for Circadian Metabolism and Cardiovascular Disease,Key Laboratory of Geriatric Cardiovascular and Cerebrovascular Diseases of Ministry of Education,Southwest Hospital,Army Medical University(Third Military Medical University),Chongqing;Department of Cardiovascular Diseases,The 960th Hospital of the PLA Joint Service Support Force,Jinan,Shandong,China)

机构地区：[1]陆军军医大学第一附属医院心血管内科,代谢生物钟与心血管疾病研究中心,老年心脑血管病教育部重点实验室,重庆 [2]联勤保障部队第九六〇医院心血管内科,山东济南

出　　处：《陆军军医大学学报》2025年第4期285-289,共5页Journal of Army Medical University

基　　金：四大慢病重大专项(2023ZD0507800);重庆市研究生科研创新项目(CYS23769)。

摘　　要：代谢性疾病是以糖脂代谢紊乱为病理生理学特征的慢性疾病,包括肥胖、糖尿病等,对人体健康构成严重威胁,亟需理论创新以指导防治窗口前移。昼夜节律作为健康机体的关键生理特性,从其调控角度出发防治代谢性疾病,已成为代谢生理学的新方向——代谢生物钟。近年来,国内外学者推动昼夜节律研究,在细胞内机制、跨器官机制及生活方式干预等方面取得显著进展。本文聚焦于细胞器调节、器官间与细胞间生物钟通讯以及限时进食的分子机制,阐述代谢生物钟领域的最新成果,并提出中枢神经与外周器官、外周器官间生物钟的相互作用是解析生物钟调控代谢稳态机制的核心科学问题。攻克这一难题,将为实现代谢稳态的精准时间干预提供关键靶点,为指导合理进食与运动以防治代谢性疾病提供全新理论依据。Metabolic diseases,including obesity and diabetes,etc.,are a spectrum of life-threatening diseases,in which metabolic dysfunction is a hallmark.It is in urgent need of new insights for the prevention and treatment of the diseases.Circadian rhythm is fundamental in health and wellbeing.Research on circadian rhythm has shed light on metabolic homeostasis,thereby giving birth to a new direction,named circadian metabolism.Here,we summarize recent advances in circadian metabolism regarding organelle regulation,inter-and intra-organ crosstalk of circadian clocks,as well as molecular mechanisms of time-restricted eating,and propose circadian communication across the hierarchy of central and peripheral clocks as a key concept for understanding the temporal regulation of metabolism.The underlying mechanisms on circadian communication should shed light on precision medicine in a temporal resolution and provide guidelines on when to eat and when to exercise for the prevention of metabolic diseases.

关 键 词：昼夜节律 生物钟 糖脂代谢 代谢性疾病 

分 类 号：R338.2[医药卫生—人体生理学] R338.6[医药卫生—基础医学] R339.6