siRNA无载体递送研究进展  

Study Advance in siRNA Carrier-Free Delivery

作　　者：刘珂瑶 罗应楠 胡一雪 王东纳 张列峰[1,2] Liu Keyao;Luo Yingnan;Hu Yixue;Wang Dongna;ZhangLiefeng(School of Food and Pharmaceutical Engineering,Nanjing Normal University,Nanjing 210023,China;School of Life Sciences,Nanjing Normal University,Nanjing 210023,China)

机构地区：[1]南京师范大学食品与制药工程学院,江苏南京210023 [2]南京师范大学生命科学学院,江苏南京210023

出　　处：《南京师大学报(自然科学版)》2025年第1期47-55,共9页Journal of Nanjing Normal University(Natural Science Edition)

基　　金：国家自然科学基金项目(21877061)。

摘　　要：小干扰RNA(small interfering RNA,siRNA)作为一种能够特异性靶向基因沉默的重要分子,具有广阔的应用前景.然而,siRNA的有效递送一直是其临床应用的关键问题之一.传统的siRNA递送系统通常依赖于载体工具的辅助,但载体存在潜在的降解性、长期毒性和免疫反应等问题,限制了其在临床中的应用.因此,无载体递送siRNA成为当前研究的热点之一.本综述旨在回顾siRNA无载体递送研究的最新进展,包括其作用机制、递送策略以及递送优势等方面.Small interfering RNA(siRNA),as an important molecule capable of specific gene silencing,holds great promise in various applications.However,the effective delivery of siRNA has always been one of the key issues for its clinical application.Traditional siRNA delivery systems often rely on carrier vehicles,but these carriers have potential issues such as degradation,long-term toxicity and immune response,which restrict their clinical use.Therefore,carrier-free delivery of siRNA has become one of the research hotspots.This review aims to summarize the latest advances in siRNA carrier-free delivery research,including mechanism of action,delivery strategies and delivery advantages.

关 键 词：小干扰RNA 无载体递送 RNA干扰 修饰策略 siRNA偶联物 

分 类 号：R945[医药卫生—微生物与生化药学]