阻塞性睡眠呼吸暂停对眼底疾病影响的研究进展  

Research advances on the impact of obstructive sleep apnea on ocular fundus diseases

作　　者：庞雪艺(综述) 曹云山[2] 张琰(审校) Pang Xueyi;Cao Yunshan;Zhang Yan(Tianjin Key Laboratory of Retinal Functions and Diseases,Tianjin Branch of National Clinical Research Center for Ocular Disease,Eye Institute and School of Optometry,Tianjin Medical University Eye Hospital,Tianjin 300384,China;Department of Cardiology,Pulmonary Vascular Disease Center(PVDC),Gansu Provincial Hospital,Lanzhou 730000,China)

机构地区：[1]天津医科大学眼科医院、眼视光学院、眼科研究所、国家眼耳鼻喉疾病临床医学研究中心、天津市分中心、天津市视网膜功能与疾病重点实验室,天津300384 [2]甘肃省人民医院心脏科、甘肃省人民医院肺血管疾病中心(PVDC),兰州730000

出　　处：《中华实验眼科杂志》2025年第1期80-86,共7页Chinese Journal Of Experimental Ophthalmology

基　　金：天津市卫生健康科技项目(TJWJ2024RC006);天津市医学重点学科(专科)建设(TJYXZDXK-037A);天津医科大学眼科医院高水平创新型人才计划:第二层次(YDYYRCXM-B2023-01)。

摘　　要：阻塞性睡眠呼吸暂停(OSA)是一种常见的睡眠障碍疾病,与青光眼视神经病变、非动脉炎性前部缺血性视神经病变、糖尿病视网膜病变、中心性浆液性脉络膜视网膜病变、视网膜静脉阻塞等多种眼底疾病密切相关。OSA影响眼底疾病的主要机制与间歇性缺氧、交感神经系统激活、全身氧化应激以及炎症反应有关,但具体机制仍待进一步探索。持续气道正压通气治疗可改善OSA患者眼底症状,并降低疾病进展的风险。因此,临床医师需要认识到OSA与眼底疾病之间的相关性,了解其对眼底疾病的影响,进而实现对OSA引起的眼底疾病的早诊断和早治疗,降低视觉受损和致盲的风险。Obstructive sleep apnea(OSA)is a common sleep disorder that is closely associated with ocular fundus diseases such as glaucomatous optic neuropathy,nonarteritic anterior ischemic optic neuropathy,diabetic retinopathy,central serous chorioretinopathy and retinal vein occlusion.The main mechanisms by which OSA affects fundus diseases include intermittent hypoxia,activation of sympathetic nervous system,systemic oxidative stress,and inflammatory response,but the specific mechanisms require further investigation.The therapeutic modality such as continuous positive airway pressure can alleviate the symptoms of ocular fundus diseases in the patients with OSA and reduce the risk of disease progression.Therefore,clinicians should recognize the relationship between OSA and fundus diseases,understand the impact of OSA on these diseases,and achieve early diagnosis and treatment of the OSA-associated fundus diseases to reduce the risk of severe visual impairment and blindness.

关 键 词：阻塞性睡眠呼吸暂停 青光眼视神经病变 非动脉炎性前部缺血性视神经病变 糖尿病视网膜病变 中心性浆液性脉络膜视网膜病变 视网膜静脉阻塞 

分 类 号：R766[医药卫生—耳鼻咽喉科] R773.4[医药卫生—临床医学]