Bioinformatic Resources for Exploring Human-virus Protein-protein Interactions Based on Binding Modes  

作　　者：Huimin Chen Jiaxin Liu Gege Tang Gefei Hao Guangfu Yang 

机构地区：[1]State Key Laboratory of Green Pesticide,International Joint Research Center for Intelligent Biosensor Technology and Health,Central China Normal University,Wuhan 430079,China [2]State Key Laboratory of Green Pesticide,Key Laboratory of Green Pesticide and Agricultural Bioengineering,Ministry of Education,Center for Research and Development of Fine Chemicals,Guizhou University,Guiyang 550025,China

出　　处：《Genomics, Proteomics & Bioinformatics》2024年第5期45-59,共15页基因组蛋白质组与生物信息学报(英文版)

基　　金：supported by the National Natural Science Foundation of China(Grant No.32125033).

摘　　要：Historically,there have been many outbreaks of viral diseases that have continued to claim millions of lives.Research on human-virus protein-protein interactions(PPIs)is vital to understanding the principles of human-virus relationships,providing an essential foundation for developing virus control strategies to combat diseases.The rapidly accumulating data on human-virus PPIs offer unprecedented opportunities for bioinformatics research around human-virus PPIs.However,available detailed analyses and summaries to help use these resources systematically and efficiently are lacking.Here,we comprehensively review the bioinformatic resources used in human-virus PPI research,and discuss and compare their functions,performance,and limitations.This review aims to provide researchers with a bioinformatic toolbox that will hopefully better facilitate the exploration of human-virus PPIs based on binding modes.

关 键 词：Artificial intelligence Bioinformatic resource Protein-protein docking Protein-protein interaction Viral pandemic 

分 类 号：Q811.4[生物学—生物工程]