异丙酚与七氟醚对妇科癌症手术切除患者术后免疫细胞功能的影响  

Effects of propofol and sevoflurane used in the surgical resection of the gynecological cancer of patients on their postoperative immune cell function

作　　者：叶秀丽 李立芊 阮惠娟 朱淑华 程高升 朱燕琴 YE Xiuli;LI Liqian;RUAN Huijuan;ZHU Shuhua;CHENG Gaosheng;ZHU Yanqin(Fuzhou First General Hospital,Fujian Province,350009)

机构地区：[1]福建省福州市第一总医院,350009

出　　处：《中国计划生育学杂志》2025年第2期285-288,共4页Chinese Journal of Family Planning

基　　金：福建省自然科学基金项目(2022J011302)。

摘　　要：目的:探讨异丙酚与七氟醚对妇科癌症手术患者免疫细胞功能的影响。方法:选择2022年8月-2024年2月本院接受妇科癌症手术切除患者90例,随机数表法分为两组各45例,分别为术中采用异丙酚麻醉诱导及麻醉维持(异丙酚组)、七氟醚吸入麻醉及麻醉维持(七氟醚组)。比较两组围术期情况、术后麻醉恢复情况、不同时点免疫细胞功能变化及麻醉相关不良反应发生率。结果:七氟醚组自主呼吸恢复(21.22±3.41 min)、拔管(30.34±4.71min)、定向力恢复(36.17±3.20min)均短于异丙酚组(25.37±4.10min、34.67±3.23min、40.26±3.65min);两组术后1h、24h时CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均低于麻醉诱导前,但七氟醚组均高于异丙酚组(均P<0.05);不良反应总发生率两组(8.9%、6.7%)无差异(P>0.05)。结论:与异丙酚相比,七氟醚对妇科癌症手术切除患者免疫细胞功能的影响更小。Objective: To investigate the effects of propofol and sevoflurane used in the surgical resection of the gynecological cancer of patients on their postoperative immune cell function. Methods: A total of 90 patients with gynecological cancer who wanted surgical resection in the hospital were selected and were divided into two groups(45 cases in each group) by the random number table method from August 2022 to February 2024. The patients in group A were given propofol anesthesia induction and anesthesia maintenance during surgery, and the patients in group B were given sevoflurane inhalation anesthesia and anesthesia maintenance during surgery. The perioperative conditions, the postoperative anesthesia recovery, the immune cell function changes at different time points and the incidence of the anesthesia-related adverse reactions of the patients were compared between the two groups. Results: The spontaneous breathing recovery time(21.22±3.41 min), the extubation time(30.34±4.71 min) and the orientation recovery time(36.17±3.20 min) of the patients in the sevoflurane group were significantly shorter than those(25.37±4.10 min、34.67±3.23 min and 40.26±3.65 min) of the patients inthe propofol group. The levels of CD3^(+), CD4^(+) and CD4^(+)/CD8^(+) of the patients in the two groups at 1h and 24h after surgery were significantly lower than those before anesthesia induction, but which of the patients in the sevoflurane were significantly higher than those in the propofol group(all P<0.05). There was no significant difference in the total incidence of adverse reactions(8.9% vs. 6.7%) of the patients between the two groups(P>0.05). Conclusion: Compared with that of propofol, sevoflurane used in the surgical resection of the gynecological cancer of the patients has less influence on their postoperative immune cell function.

关 键 词：妇科癌症手术 麻醉 异丙酚 七氟醚 免疫细胞功能 不良反应 

分 类 号：R614[医药卫生—麻醉学] R737.3[医药卫生—外科学]