口咽初乳滴注联合微生态制剂治疗喂养不耐受早产儿效果及对胃肠激素及免疫功能影响  

Effect of oropharyngeal colostrum infusion combined with microecological preparation for treating premature infants with feeding intolerance and its influence on the gastrointestinal hormones and immune function of these infants

作　　者：程凤娜[1] 王小娟[1] 张莉莉[1] CHENG Fengna;WANG Xiaojuan;ZHANG Lili(Shanxi Provincial People's Hospital,Xi'an,ShanxiProvince,710068)

机构地区：[1]陕西省人民医院,西安710068

出　　处：《中国计划生育学杂志》2025年第2期341-345,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨口咽初乳滴注联合微生态制剂对喂养不耐受早产儿胃肠激素及免疫功能的影响。方法:选取2021年1月-2023年12月在本院新生儿科进行治疗的对喂养不耐受早产儿135例,简单随机分为联合组(n=68)和参照组(n=67),两组均给予早产儿微生态制剂治疗,联合组同时行口咽初乳滴注干预。比较喂养不耐受早产儿治疗效果,治疗前后免疫功能指标及胃肠激素水平[胃动素(MTL)、胃泌素(GAS)]。结果:联合组治疗总有效率(97.1%)高于对照组(88.1%),两组免疫指标CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均升高,CD8^(+)下降且联合组变化幅度大于对照组,两组胃肠激素MTL、GAS水平均升高且联合组(365.61±50.47 ng/L、136.52±25.32 ng/L)高于对照组(316.78±49.53 ng/L、119.26±19.84 ng/L)(均P<0.05)。结论:口咽初乳滴注联合微生态制剂治疗喂养不耐受早产儿效果提高,可促进患儿机体免疫功能及胃肠功能提高。Objective: To investigate the influence of oropharyngeal colostrum infusion combined with microecological preparation for treating premature infants with feeding intolerance on their gastrointestinal hormones and immune function. Methods: 135 premature infants with feeding intolerance who were treated in the department of neonatology of the hospital were selected and were divided into study group(n=68) and control group(n=67) by simple randomization method from January 2021 to December 2023. The infants in the two groups were treated with microecological preparation, while the infants in the study group were treated with oropharyngeal colostrum infusion intervention additionally. The therapeutic effect, and the immune function indexes and the levels of the gastrointestinal hormones, such as motilin(MTL) and gastrin(GAS) before and after treatment of the infants were compared between the two groups. Results: The total effective rate(97.1%) of the infants in the study group was significantly higher than that(88.1%) of the infants in the control group. The values of the immune indicators, such as CD3^(+), CD4^(+) and CD4^(+)/CD8^(+), of the infants in the two groups had increased significantly, and the CD8^(+) value of the infants in the two groups had decreased significantly, and the change ranges of which of the infants in the study group were significantly more than those of the infants in the control group. The levels of the gastrointestinal hormones, such as MTL and GAS, of the infants in the two groups had increased significantly, and which(365.61±50.47 ng/L and 136.52±25.32 ng/L) of the infants in the study group were significantly higher than those(316.78±49.53 ng/L and 119.26±19.84 ng/L) of the infants in the control group(all P<0.05). Conclusion: Oropharyngeal colostrum infusion combined with microecological preparation for treating the premature infants with feeding intolerance can improve their therapeutic effect, and which can promote the immune and gastrointestinal function of these premature infan

关 键 词：喂养不耐受早产儿 初乳 口咽滴注 微生态制剂 胃肠激素 免疫功能 

分 类 号：R72[医药卫生—儿科]