克拉霉素结合桂枝茯苓胶囊治疗慢性盆腔炎症疗效及对患者阴道微环境和免疫功能影响  

Efficacy of clarithromycin combined with Guizhi fuling capsule for treating patients with chronic pelvic inflammatory disease and its influence on their vaginal microenvironment and immune function

作　　者：伍贵红 蓝晓明 蓝素秋 WU Guihong;LAN Xiaoming;LAN Suqiu(Zhejiang University of Traditional Chinese Medicine,Hangzhou,Zhejiang Province,310053;Longyou Maternity and Child Care Hospital,Zhejiang Province)

机构地区：[1]浙江中医药大学,杭州310053 [2]浙江省龙游县妇幼保健院

出　　处：《中国计划生育学杂志》2025年第2期356-360,共5页Chinese Journal of Family Planning

摘　　要：目的:探究克拉霉素结合桂枝茯苓胶囊治疗慢性盆腔炎症疗效及对患者阴道微环境和免疫功能的影响。方法:回顾性分析2022年6月-2023年6月于浙江省龙游县妇幼保健院就诊的慢性盆腔炎症患者102例临床病例资料,接受常规克拉霉素治疗50例为对照组,接受克拉霉素结合桂枝茯苓胶囊治疗的52例为联合组,比较两组治疗前后炎症因子水平[白介素-17(IL-17)、超敏C反应蛋白(hs-CRP)、转化生长因子-β(TGF-β)],阴道微环境(阴道pH值、菌群密集度、菌群多样性),免疫功能(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))变化以及治疗期间不良反应。结果:经治疗后,两组IL-17、hs-CRP、TGF-β低于对照组(33.18±4.62 ng/ml、14.23±3.42 mg/L、54.52±8.02 ng/L),阴道pH值、菌群多样性优于对照组(均P<0.05),两组菌群密集度变化无差异(P>0.05);联合组CD3^(+)(52.67±5.12)%、CD4^(+)(54.38±5.43)%、CD4^(+)/CD8^(+)(1.94±0.22)水均高于对照组(49.41±4.65%、50.74±4.81%、1.75±0.19),CD8^(+)(26.02±2.41)%低于对照组(28.183.23)%(均P<0.05);治疗期间,两组均出现轻微不良反应,但总发生率(17.2%比14.0%)无差异(P>0.05)。结论:克拉霉素结合桂枝茯苓胶囊治疗慢性盆腔炎症可有效减少患者炎症反应,有助于恢复阴道微生态平衡,改善免疫功能,安全性良好。Objective: To explore the efficacy of clarithromycin combined with Guizhi fuling capsule for treating patients with chronic pelvic inflammatory disease, and to study its influence on the vaginal microenvironment and immune function of the patients. Methods: The clinical data of 102 patients with chronic pelvic inflammatory disease who were treated in the hospital from June 2022 to June 2023 were analyzed retrospectively. 50 patients who received the conventional clarithromycin therapy were enrolled in control group and 52 patients who were treated with clarithromycin combined with Guizhi fuling capsule were enrolled in study group. The levels of the inflammatory factors, such as interleukin-17(IL-17), high-sensitivity C-reactive protein(hs-CRP) and transforming growth factor(TGF), the vaginal microenvironment, such as vaginal pH value, flora density and flora diversity, and the values of the immune function, such as the CD3^(+), CD4^(+), CD8^(+) and CD4^(+)/CD8^(+), before and after treatment, and the adverse reactions rate of the patients during treatment were compared between the two groups. Results: After treatment, the levels of IL-17, hs-CRP and TGF of the patients in the study group were significantly lower than those(33.18±4.62 ng/ml, 14.23±3.42 mg/L and 54.52±8.02 ng/L) of the patients in the control group. The vaginal pH value and the diversity of bacterial flora of the patients in the study group were significantly better than those of the patients in the control group(all P<0.05). There was no significant difference in the density of bacteria of the patients between the two groups(P>0.05). The values of CD3^(+)(52.67±5.12%),CD4^(+)(54.38±5.43%),CD4^(+)/CD8^(+)(1.94±0.22)of the patients in the study group were significantly higher than those(49.41±4.65%,50.74±4.81% and 1.75±0.19)of the patients in the control group.The CD8^(+)value(26.02±2.41%)of the patients in the study group was significantly lower than that(28.18±3.23%)of the patients in the control group(all P<0.05).During the treatment,

关 键 词：慢性盆腔炎 克拉霉素 桂枝茯苓胶囊 阴道微环境 免疫功能 炎症反应 

分 类 号：R711.33[医药卫生—妇产科学]