PE患者血清PP8、PP14水平及其与剖产术后下肢深静脉血栓的关系  

Correlation between the levels of the serum placental protein 8 and placental protein 14 of pregnant women with preeclampsia and their lower extremity deep vein thrombosis occurrence after cesarean section

作　　者：刘欣悦 王月 刘春稳 徐闻铂 任艳华 孙志敏 王新彦 LIU Xinyue;WANG Yue;LIU Chunwen;XU Wenbo;REN Yanhua;SUN Zhimin;WANG Xinyan(Cangzhou Maternal and Child Health Care Hospital,Cangzhou,HebeiProvince,061000)

机构地区：[1]河北省沧州市妇幼保健院,061000

出　　处：《中国计划生育学杂志》2025年第2期409-413,共5页Chinese Journal of Family Planning

基　　金：河北省医学科学研究课题(20241789);沧州市重点研发计划指导项目(222106053)。

摘　　要：目的:探讨血清胎盘蛋白8(PP8)、PP14水平对子痫前期(PE)剖产术后发生下肢深静脉血栓(LEDVT)的预测价值。方法:选取2020年1月-2023年12月在本院行剖宫产分娩的PE患者105例临床资料,根据患者产后是否发生LEDVT分为非LEDVT组(n=85)与LEDVT组(n=20)。收集两组临床资料并检测患者术前血清PP8、PP14水平,采用受试者工作特性(ROC)曲线评估血清PP8、PP14对PE患者剖产术后发生LEDVT的预测价值,多因素logistic回归分析PE患者剖产术后发生LEDVT的影响因素。结果:LEDVT组血清PP8(196.41±20.06 pg/ml)、PP14(285.93±32.53 pg/L)均高于非LEDVT组(154.83±17.27 pg/ml、173.62±26.45 pg/L)(均P<0.05);ROC曲线分析,血清PP8、PP14及两项联合预测PE患者剖产术后发生LEDVT的曲线下面积分别为0.786、0.814、0.929。多因素分析,产褥期卧床时间≥3d,产后出血,血清PP8≥174.23pg/ml,血清PP14≥226.74pg/L是PE患者剖产术后LEDVT的危险因素(均P<0.05)。结论:PE患者剖宫产术前血清PP8、PP14水平上升与术后发生LEDVT密切相关,两者联合可作为预测PE患者剖产术后发生LEDVT的生物学标志物。Objective: To investigate the predictive value of the levels of serum placental protein 8(PP8) and PP14 levels of pregnant women with preeclampsia(PE) for their lower extremity deep vein thrombosis(LEDVT) occurrence after cesarean section. Methods: The clinical data of 105 pregnant women with PE who were delivered by cesarean section in the hospital from January 2020 to December 2023 were selected in this study. According to whether LEDVT of the women occurred or not after delivery, these women were divided into two groups, including 85 women without LEDVT in group A and 20 women with LEDVT in group B. The clinical data of the women in the two groups were collected. The levels of serum PP8 and PP14 of the women in the two groups before operation were detected. Receiver operating characteristic(ROC) curve was used to evaluate the predictive value of the serum PP8 and PP14 levels of the women for their LEDVT occurrence after cesarean section. Multivariate logistic regression was used to analyze the influencing factors of the LEDVT occurrence of the women with PE after cesarean section. Results: The serum levels of PP8(196.41±20.06 pg/ml) and PP14(285.93±32.53 pg/L) of the women in group B were significantly higher than those(154.83±17.27 pg/ml and 173.62±26.45 pg/L) of the women in group A(all P<0.05). ROC curve analysis showed that the area under the curve of the PP8 level, the PP14 level and the combination of the PP8 and PP14 levels of the women with PE for predicting their LEDVT occurrence after cesarean section were 0.786, 0.814 and 0.929, respectively. Multivariate analysis showed that the puerperium rest time in bed≥3 days, the postpartum hemorrhage, the serum PP8 level ≥74.23pg/ml and the PP14 level≥226.74pg/L of the women with PE were the risk factors of their LEDVT occurrence after cesarean section(all P<0.05).Conclusion:The increased levels of the preoperative serum PP8and PP14of the pregnant women with PE are closely related to their LEDVT occurrence,and the combination of the PP8and PP14level

关 键 词：子痫前期 剖宫产术 术后下肢深静脉血栓 胎盘蛋白8 胎盘蛋白14 预测价值 危险因素 

分 类 号：R719.8[医药卫生—妇产科学] R714.244[医药卫生—临床医学]