经腹部彩色多普勒超声联合血清Ca199、HE4检测鉴别诊断卵巢肿瘤价值  

Value of the transabdominal color Doppler ultrasound combined with the levels of serum carbohydrate antigen 199 and human epididymal protein 4 of patients for differential diagnosing their ovarian tumors

作　　者：梁翠花 王云龙 孙华杰 王赛男 LIANG Cuihua;WANG Yunlong;SUN Huajie;WANG Sainan(Taihe County People's Hospital,Fuyang,Anhui Province,236600)

机构地区：[1]安徽省太和县人民医院,236600

出　　处：《中国计划生育学杂志》2025年第2期449-453,共5页Chinese Journal of Family Planning

摘　　要：目的:探究经腹部彩色多普勒超声联合血清糖类抗原199(Ca199)、附睾蛋白4(HE4)检测诊断卵巢肿瘤价值。方法:回顾性收集2022年1月-2024年8月本院就诊的卵巢肿瘤和卵巢囊肿患者临床资料,根据病理检查结果分为囊肿组(43例)与肿瘤组(33例),检测患者血清Ca199,HE4水平,采用Kappa检验分析彩色多普勒超声、血清Ca199及HE4水平对卵巢肿瘤的诊断结果,logistics分析卵巢肿瘤的影响因素,受试者工作特征(ROC)曲线分析彩色多普勒超声、血清Ca199、HE4联合检测诊断卵巢肿瘤价值。结果:肿瘤组血清Ca199(58.38±18.73 U/ml)、HE4(78.72±19.81 pmol/L)水平均高于囊肿组(27.81±12.68 U/ml、44.19±16.23 pmol/L)(均P<0.05);彩色多普勒超声联合血清Ca199、HE4检测诊断卵巢肿瘤与病理诊断的一致性高于单独检测(Kappa值=0.713,P<0.05);形态规则是卵巢肿瘤的保护因素(OR=0.544),Ca199升高、HE4升高是卵巢肿瘤的危险因素(OR=2.885、3.490)(均P<0.05)。彩色多普勒超声联合血清Ca199、HE4检测诊断卵巢肿瘤的曲线下面积为0.928,敏感度93.9%、特异度79.1%,且诊断价值高于单独指标诊断(P<0.05)。结论:卵巢肿瘤患者血清Ca199、HE4水平升高,经腹部彩色多普勒超声联合、血清Ca199、HE4检测鉴别诊断卵巢肿瘤的临床价值较高。Objective: To explore the value of the transabdominal color Doppler ultrasound combined with the levels of serum carbohydrate antigen 199(CA199) and human epididymal protein 4(HE4) of patients for differential diagnosing their ovarian tumors. Methods: The clinical data of the patients with ovarian tumors or ovarian cysts treated in the hospital from January 2022 to August 2024 were collected retrospectively. According to the results of the pathological examination, these patients were divided into group A(patients with ovarian tumors) and group B(patients with ovarian cysts). The serum Ca199 and HE4 levels of the patients in the two groups were detected. The diagnostic values of the color Doppler ultrasound, and the serum Ca199 and HE4 levels of the patients for their ovarian tumors were analyzed by Kappa test. Logistics was used to analyze the influencing factors of the ovarian tumors of the patients. Receiver operating characteristic(ROC) curve was used to analyze the value of the color Doppler ultrasound combined with the levels of serum Ca199 and HE4 of the patients for diagnosing their ovarian tumors. Results: The serum levels of CA199(58.38±18.73 U/ml) and HE4(78.72±19.81 pmol/L) of the patients in group A were significantly higher than those(27.81±12.68 U/ml and 44.19±16.23 pmol/L) of the patients in group B(all P<0.05). The consistency between the color Doppler ultrasound combined with the levels of serum Ca199 and HE4 of the patients and their pathology for diagnosing their ovarian tumors was significantly higher than that of the color Doppler ultrasound combined or the levels of serum Ca199 and HE4 alone(Kappa value =0.713, P<0.05). The lesion with the regular shape found by the color Doppler ultrasound of the patients was a protective factor of their ovarian tumors(OR=0.544),but the increased levels CA199and HE4of the patients were the risk factors of their ovarian tumors(OR=2.885,3.490)(all P<0.05).The area under the curve,the sensitivity and the specificity of the color Doppler ultrasound combine

关 键 词：卵巢肿瘤 彩色多普勒超声 糖类抗原199 附睾蛋白4 鉴别诊断 影响因素 

分 类 号：R445.1[医药卫生—影像医学与核医学] R737.31[医药卫生—诊断学]