PCOS孕妇血清AMH、LH/FSH、HOMA-IR水平及其对妊娠结局的影响  

Influence of the serum anti Mullerian hormone level, the luteinizing hormone /follicle stimulating hormone ratio and the homeostatic insulin assessment model insulin resistance value of pregnant women with polycystic ovary syndrome on their pregnancy outco

作　　者：綦萍 王璇 刘钦文 QI Ping;WANG Xuan;LIU Qinwen(Qingdao Jiaozhou Central Hospital,Shandong Province,266300)

机构地区：[1]青岛市胶州中心医院,266300

出　　处：《中国计划生育学杂志》2025年第2期468-472,共5页Chinese Journal of Family Planning

基　　金：青岛市医疗卫生重点学科建设项目。

摘　　要：目的:分析多囊卵巢综合征(PCOS)孕妇血清抗苗勒管激素(AMH)、黄体生成素(LH)/卵泡刺激素(FSH)比值及稳态胰岛素评估模型胰岛素抵抗(HOMA-IR)指数水平及其对妊娠结局的影响。方法:回顾性收集2021年1月-2023年1月本院规律产前检查孕妇临床资料,其中PCOS患者121例为病例组,正常妊娠孕妇60例为对照组。根据PCOS患者妊娠结局分为不良组(n=41)和良好组(n=80)。收集各组临床资料以及首次入院检查时血清AMH、LH/FSH及HOMA-IR等资料,比较不同组别临床资料并分析PCOS孕妇血清AMH、LH/FSH、HOMA-IR水平变化与妊娠结局关系。结果:病例组体质指数(BMI)、AMH、LH/FSH、HOMA-IR水平均均高于对照组,且病例组中妊娠不良组上述各指标均高于妊娠良好组(均P<0.05);经logistic回归分析,AMH、LH/FSH、HOMA-IR水平升高均为PCOS患者发生不良妊娠结局的独立影响因素(均P<0.05)。结论:PCOS孕妇血清AMH、LH/FSH、HOMA-IR均异常升高,且均为患者不良妊娠结局发生危险因素。临床可通过早期检测对患者妊娠结局进行预测和指导。Objective: To analyze the influence of the serum anti Mullerian hormone(AMH) level, the luteinizing hormone(LH)/follicle stimulating hormone(FSH) ratio and the homeostatic insulin assessment model insulin resistance(HOMA-IR) value of pregnant women with polycystic ovary syndrome on their pregnancy outcomes. Methods: The clinical data of the pregnant women who had received regular prenatal examinations in the hospital from January 2021 to January 2023 were collected in this study retrospectively. Among them, 121 pregnant women with PCOS were selected in the study group and 60 normal pregnant women were selected in the control group. According to the pregnancy outcomes, the women in the study group were divided into group A(41 women with adverse pregnancy outcomes) and group B(80 women with normal pregnancy outcomes). The clinical data, the serum AMH level, the LH/FSH ratio and the HOMA-IR value of the women in these groups at the first admission examination were collected. The clinical data of the women were compared among these groups. The correlation between the changes of the serum AMH level, the LH/FSH ratio and the HOMA-IR value of the pregnant women with PCOS and their pregnancy outcomes was analyzed. Results: The body mass index(BMI) value, the serum AMH level, the LH/FSH ratio and the HOMA-IR value of the women in the study group were significantly higher than those of the women in the control group, and which of the women in group A were significantly higher than those of the women in group B(all P<0.05). Logistic regression analysis found that the AMH level, the LH/FSH ratio and the HOMA-IR value of the women with PCOS were the independent factors influencing their adverse pregnancy outcomes(all P <0.05).Conclusion:The serum AMH level,the LH/FSH ratio and the HOMA-IR value of the women with PCOS are all elevated abnormally,and all of which are the risk factors of the adverse pregnancy outcomes of the women.The early detections of the serum AMH level,the LH/FSH ratio and the HOMA-IR value of the women wit

关 键 词：多囊卵巢综合征 抗苗勒管激素 黄体生成素/卵泡刺激素比值 胰岛素抵抗指数 不良妊娠结局 影响 

分 类 号：R711.75[医药卫生—妇产科学] R714.2[医药卫生—临床医学]