多次反射飞行时间质谱仪高性能矩形离子阱的研制  

Development of A High-performance Rectangular Ion Trap for Multi-reflection Time-of-Flight Mass Spectrometer

作　　者：陈小霞 任熠 黄奇 向大军 李长伟 洪义 李磊[1,2] 黄正旭 李梅[1,4] 徐经纬 周振[1,4] CHEN Xiao-Xia;REN Yi;HUANG Qi;XIANG Da-Jun;LI Chang-Wei;HONG Yi;LI Lei;HUANG Zheng-Xu;LI Mei;XU Jing-Wei;ZHOU Zhen(School of Environment and Climate,Jinan University,Guangzhou 510632,China;Guangzhou MS Institute of Scientific Instrument Innovation,Guangzhou 510700,China;Guangzhou Hexin Instrument Co.Ltd.,Guangzhou 510530,China;Guangdong Provincial Engineering Research Center for Online Source Apportionment System of Air Pollution,Guangzhou 510632,China)

机构地区：[1]暨南大学环境与气候学院,广州510632 [2]广东省麦思科学仪器创新研究院,广州510700 [3]广州禾信仪器股份有限公司,广州510530 [4]广东省大气污染在线源解析系统工程技术研究中心,广州510632

出　　处：《分析化学》2025年第1期38-46,共9页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(No.41827804)资助。

摘　　要：作为新一代飞行时间质谱,多次反射飞行时间质谱(MR-TOF MS)因具有超高分辨率和快速分析能力在核物理、化学和生物学等领域得到了越来越广泛的应用。然而,MR-TOF MS的分析性能在很大程度上取决于进入质量分析器的离子团状态。本研究采用印刷电路板技术设计开发了一种矩形离子阱(RIT),以其作为离子收集和聚焦装置,可在离子进入质量分析器前对离子进行收集、冷却和抛出。相比于由两组平面电极构成的离子阱,此RIT的电压利用效率更高,可更充分实现离子的收集和聚焦。实验结果表明,此RIT的工作周期、离子通量和离子聚焦状态均满足MR-TOF质量分析器的要求,与其耦合后,离子经多次反射后的质量分辨率可达到1.5×10^(5)。As a new generation of time-of-flight mass spectrometry,multiple-reflection time-of-flight mass spectrometry(MR-TOF-MS)has been increasingly applied in the fields such as nuclear physics,chemistry,and biology due to its ultra-high resolution and rapid analysis capabilities.However,the analytical performance of MRTOF-MS largely depends on the ion bunch state entering the mass analyzer.In this study,a rectangular ion trap(RIT)was developed,designed and processed using printed circuit board technology,as an ion accumulating and focusing device for MR-TOF mass analyzer.Compared to traditional ion traps composed of two sets of planar electrodes,this RIT had higher voltage utilization efficiency,resulting in more efficient ion collection and focusing.The ions were cooled to a sufficiently small bunch for precise mass measurement with MR-TOF-MS mass spectrometry in only 1 ms of cooling time in the RIT,then orthogonally ejected to the MR-TOF mass spectrometer for mass analysis.Experimental results indicated that the working cycle,ion flux,and ion focusing state of the RIT fully met the requirements of the MR-TOF mass analyzer.When coupled with the MR-TOF mass analyzer,the RIT enabled MR-TOF-MS to achieve a mass resolution of 1.5×10^(5).

关 键 词：矩形离子阱 离子传输 质量范围 质量分辨率 多次反射飞行时间质谱 

分 类 号：TH843[机械工程—仪器科学与技术]