宫颈癌体内外模型研究进展  

Research progress of cervical cancer models in vitro and in vivo

作　　者：高杰 刘珉宇 邓轶方 GAO Jie;LIU Min-yu;DENG Yi-fang(State Key Laboratory of New Drug and Pharmaceutical Process,Shanghai Institute of Pharmaceutical Industry,China State Institute of Pharmaceutical Industry,Shanghai 200437,China;Shanghai Professional and Technical Service Center for Biological Material Drug-ability Evaluation,Shanghai Institute of Pharmaceutical Industry,China State Institute of Pharmaceutical Industry,Shanghai 200437,China)

机构地区：[1]中国医药工业研究总院创新药物与制药工艺国家重点实验室,上海200437 [2]上海市生物物质成药性评价技术服务平台,上海200437

出　　处：《中国新药杂志》2025年第2期147-152,共6页Chinese Journal of New Drugs

摘　　要：女性的生殖系统中,宫颈占据着举足轻重的地位,在呵护女性健康方面起着至关重要的作用。然而,宫颈会不断受到各种微生物的入侵,最终产生病变,发展为宫颈癌。作为威胁女性健康的重大危险因素,宫颈癌引起了人们的广泛关注。事实上,绝大多数的宫颈癌都是由于感染了人乳头状瘤病毒(human papilloma virus, HPV)所致。科学家们也一直致力于构建合适的体内外模型,研究HPV的感染、宫颈癌的发生以及发展等过程。本综述主要介绍了宫颈癌的疾病背景以及目前基于宫颈疾病研究的相关体内外模型,包括转基因小鼠模型、异种移植模型、基于细胞系的细胞培养模型和类器官模型。In the female reproductive system,the cervix occupies a pivotal position,and it plays a vital role in protecting women's health.However,the cervix will be invaded by various microorganisms constantly,which will eventually cause lesions and develop into cervical cancer.As a major risk factor threatening women's health,cervical cancer has attracted widespread attention.In fact,the vast majority of cervical cancers are caused by infection with the human papilloma virus(HPV).Scientists have been working on building appropriate models in vitro and in vivo to study HPV infection,the occurrence and development of cervical cancer and other processes.This review mainly introduces the disease background of cervical cancer and the current relevant models in vivo and in vitro based on cervical disease research,including transgenic mouse models,xenograft models,cell line-based cell culture models,and organoid models.

关 键 词：宫颈癌 人乳头状瘤病毒 转基因小鼠 异种移植 细胞系 原代细胞 类器官 

分 类 号：R965.1[医药卫生—药理学]