人参鹿茸林蛙油泡腾片提高小鼠免疫力的研究  

Study on Ginseng,Pilose Antler and Rane oviductus Effervescent Tablets to Improve the Immunity of Mice

作　　者：李海燕 赵诗聪 吴香婷 金向群[2] LI Haiyan;ZHAO Shicong;WU Xiangting;JIN Xiangqun(The Affiliated Hospital of Changchun University of Chinese Medicine,Changchun 130121,China;School of Pharmacy,Jilin University,Changchun 130121,China)

机构地区：[1]长春中医药大学附属医院,吉林长春130021 [2]吉林大学药学院,吉林长春130021

出　　处：《特产研究》2025年第1期89-95,共7页Special Wild Economic Animal and Plant Research

基　　金：吉林省医药健康领域资金项目(20210204172YY)。

摘　　要：本研究旨在评价保健食品人参鹿茸林蛙油泡腾片能增强免疫力的功能。将人参鹿茸林蛙油泡腾片,经口给予小鼠(Balb/c)1.03 g(/kg·bw)、2.07 g(/kg·bw)和3.10 g(/kg·bw)灌胃(该剂量相当于人参鹿茸林蛙油泡腾片日服用剂量的10倍、20倍和30倍)30 d后进行测试。结果表明,在迟发型变态反应的小鼠试验中,经抗原攻击24 h后,试验小鼠各剂量组与对照组相比,其足跖肿胀度均显著增高。在小鼠血清溶血素试验中,与对照组小鼠相比,3.10 g/(kg·bw)剂量组的抗体积数显著增加。在小鼠抗体生成细胞检测试验中,与对照组小鼠相比,3.10 g/(kg·bw)剂量组的抗体生成细胞数显著增加。本研究结果符合保健食品评价标准,表明人参鹿茸林蛙油泡腾片具有增强免疫力功能。The aim of this study was to evaluate the immunity-enhancing function of ginseng pilose antler and forest frog oil.The effervescent tablets of ginseng,pilose antler and Rane Oviductus were administered orally to mice(Balb/c)at 1.03 g/(kg·bw),2.07 g/(kg·bw)and 3.10 g/(kg·bw)by gavage for 30 d(which were equivalent to 10,20 and 30 times of the daily dosage of ginseng,pilose antler and Rane Oviductus effervescent tablets).The results showed that in the mouse test of delayed metamorphosis,24 h after antigenic attack,all dose groups of the test mice had significantly higher foot and metatarsal swelling compared with the control group.In the mouse serum hemolysin assay,a signifiican increase in antibody accumulation was observed in the 3.10 g/(kg·bw)dose group compared to control mice.In the mouse antibody-producing cell assay,the number of antibody-producing cells was significantly increased in the 3.10 g/(kg·bw)dose group compared with the control mice.The test results were in accordance with the health food evaluation standards,and it was concluded that ginseng,pilose antler Rane Oviductus effervescent tablets had the function of enhancing immunity.

关 键 词：人参 鹿茸 林蛙油 免疫力 小鼠 

分 类 号：TS218[轻工技术与工程—粮食、油脂及植物蛋白工程]