Clinical Implications of Eosinopenia in Adult Brucellosis Patients  

作　　者：Luxuan Yang Dan Xiao Chuanwu Zhu Haiyan Wang Wenyong Zhang Jianguo Chang Meiqin Liu Xiujuan Shen 

机构地区：[1]Department of Infection Disease,The Affiliated Infectious Diseases Hospital of Soochow University,Suzhou 215000,Jiangsu Province,China [2]Department of Infection Disease,The Fifth People’s Hospital of Suzhou,Suzhou 215000,Jiangsu Province,China

出　　处：《Journal of Clinical and Nursing Research》2024年第11期266-276,共11页临床护理研究(英文)

基　　金：supported by the Suzhou Clinical Centre for Respiratory Infectious Diseases(Szlcyxzx202108);the Suzhou Youth Science and Technology Project(KJXW2023050).

摘　　要：Objective:To analyze the differences between eosinopenia and non-eosinopenia brucellosis patients in depth.Methods:Medical records of brucellosis patients admitted to the Affiliated Infectious Diseases Hospital of Soochow University between January 1,2013,and December 31,2023,were reviewed retrospectively.Patients were categorized into an eosinopenia group and a non-eosinopenia group based on pre-treatment eosinophil levels.A nonparametric test was performed to estimate the differences between the two groups.Results:Among the 125 patients,66(52.80%)experienced eosinopenia.Patients with eosinopenia were older(52.09±15.63 years vs.46.08±16.39 years,P=0.024),had a higher proportion of hypertension(21.21%vs.6.78%,P=0.024),and exhibited a greater likelihood of complications(75.76%vs.35.59%,P=0.000),particularly hematological(68.18%vs.23.73%,P=0.000)and relapse(19.70%vs.6.78%,P=0.040).The eosinopenia group also showed higher levels of ALT(29.00 vs.20.00,P=0.003),AST(29.00 vs.22.00,P=0.037),and LOS(17.50 vs.12.00,P=0.000).Among certain inflammatory indicators related to brucellosis,the eosinopenia group demonstrated lower levels,such as MPV(9.75 vs.10.70,P=0.000),MLR(0.28 vs.0.36,P=0.002),and SIRI(0.67 vs.1.03,P=0.004).Conclusion:Brucellosis patients with eosinopenia differed in clinical manifestations and prognosis.Monitoring eosinophils may provide better prognostic assessment and suggest potential new treatment options.

关 键 词：BRUCELLOSIS Eosinopenia COMPLICATION PROGNOSIS 

分 类 号：R51[医药卫生—内科学]