The Poor Performance of Neu5Gc for Endometrial Receptivity in Embryo Transfer  

作　　者：Yunfeng Lin Qicai Liu 

机构地区：[1]Department of Neonatology,Fujian Children's Hospital(Fujian Branch of Shanghai Children's Medical Center),College of Clinical Medicine for Obstetrics&Gynecology and Pediatrics,Fujian Medical University,Fuzhou 350000,China [2]Reproductive Medicine Center,the First Affiliated Hospital of Fujian Medical University,Fuzhou 350000,China [3]School of Biomedical Engineering,Tsinghua University,Beijing 100084,China [4]Key Laboratory of Clinical Laboratory Technology for Precision Medicine(Fujian Medical University),Fujian Province University,Fuzhou,China

出　　处：《Journal of Bio-X Research》2024年第3期93-96,共4页生物组学研究杂志(英文)

基　　金：supported by the National Natural Science Foundation of Fujian(nos.2023J011312,2023Y9052,and 2021J02036);Wu Jieping Medical Foundation Research Special Project(320.6750.2021-19-4).

摘　　要：Neu5Gc is a common sialic acid in mammals,but humans cannot synthesize it independently.When Neu5Gc in the diet enters the body,the body produces antibodies against Neu5Gc,which in turn promotes the immune response and chronic inflammation and may be closely related to embryo transfer rejection.Therefore,Neu5Gc has gained widespread interest from gynecologists,nutritionists,and immunologists.The same problem occurs during embryo transfer,where the embryo carries paternal gene products and is a hapten relative to the maternal endometrium.Successful implantation requires a receptive endometrial environment.Moreover,with the widespread application of in vitro fertilization and embryo transfer technology,nonhuman amino acids may be introduced into the embryo culture medium,mainly the genetic engineering-derived essential serum albumin in embryo culture medium,which may introduce the nonhuman sialic acid Neu5Gc and cause embryo transfer rejection.

关 键 词：embryo transfer paternal gene products chronic inflammation hapten relative neu gc sialic acid immune response 

分 类 号：R71[医药卫生—妇产科学] R711.6[医药卫生—临床医学]