酸枣仁汤方辨证加减治疗高血压合并睡眠障碍的药学分析  

Pharmaceutical Analysis of Modified Treatment for Hypertension Complicated with Sleep Disorder Using the Sour Jujube Kernel Decoction Based on Syndrome Differentiation

作　　者：侯爱霞[1] HOU Ai-xia(Pharmacy Department,Tai'an Traditional Chinese Medicine Hospital,Tai'an Shandong 271000,China)

机构地区：[1]泰安市中医医院药学部,山东泰安271000

出　　处：《中华养生保健》2025年第2期8-12,共5页CHINESE HEALTH CARE

摘　　要：目的探讨酸枣仁汤方辨证加减治疗高血压合并睡眠障碍的药学作用。方法在2022年1月—2023年12月从泰安市中医医院选取合并睡眠障碍的高血压患者,共选取98例,依照随机数表法进行分组,分成两组,各49例。对照组在治疗时应用常规西药治疗,研究组在西药治疗基础上选用中药汤方酸枣仁汤,随证加减。对比两组间总有效率、不良反应发生率,并对比两组治疗前后血压指标、睡眠指标、心理评分、生活质量评分、肝肾功能指标。结果研究组总有效率比对照组高(P<0.05)。研究组与对照组的不良反应总发生率对比,差异无统计学意义(P>0.05)。治疗后,对收缩压、舒张压进行测量,两组血压均低于治疗前,而研究组则低于对照组(P<0.05)。治疗后,两组夜间监测的各项睡眠数据均较同组治疗前改善,而组间对比,研究组的入睡潜伏期比对照组短,研究组的实际睡眠时长比对照组长,研究组睡眠质量评分比对照组低(P<0.05)。治疗后,两组患者的焦虑评分、抑郁评分均比同组治疗前降低,而研究组患者的两项心理分数均比对照组低(P<0.05)。治疗后,两组的生活质量,在四个维度,两组测得分数均比同组治疗前高,而研究组高于对照组(P<0.05)。两组治疗前后肝肾功能指标对比,差异无统计学意义(P>0.05),组间对比,差异无统计学意义(P>0.05)。结论在高血压合并睡眠障碍患者治疗时,选用酸枣仁汤,疗效显著,不仅能够控制血压水平,还能改善患者睡眠状况,减轻睡眠障碍,有助于改善其心理、生活质量,并且,将西药与酸枣仁汤联合应用未增加不良反应发生风险,具有良好的安全性。Objective To explore the pharmacological effects of Suanzaoren decoction with differential diagnosis and modifi cation in the treatment of hypertension combined with sleep disorders.Methods From January 2022 to December 2023,98 hypertensive patients with sleep disorders were selected from Tai'an Traditional Chinese Medicine Hospital.They were randomly divided into two groups of 49 each using a random number table.The control group received conventional Western medicine treatment during treatment,while the study group used a traditional Chinese medicine decoction called Suanzaoren decoction on the basis of Western medicine treatment,with adjustments made according to the syndrome.Compare the total effective rate and incidence of adverse reactions between the two groups,and compare blood pressure indicators,sleep indicators,psychological scores,quality of life scores,and liver and kidney function indicators before and after treatment in both groups.Results Regarding the total effective rate,the values in the study group were higher than those in the control group(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the study group and the control group(P>0.05).After treatment,systolic and diastolic blood pressure were measured,and both blood pressure were lower than before treatment,while the study group was lower than the control group(P<0.05).After treatment,various sleep data monitored at night in both groups improved compared to before treatment,and in the inter group comparison,the sleep latency of the study group was shorter than that of the control group,the actual sleep duration of the study group was longer than that of the control group,and the sleep quality score of the study group was lower than that of the control group,(P<0.05).After treatment,the anxiety score and depression score of both groups of patients decreased compared to before treatment,while the two psychological scores of the study group were lower than those of the control group(P<0

关 键 词：高血压 睡眠障碍 酸枣仁汤 中药 

分 类 号：R287[医药卫生—中药学]