新癀片调醋外敷预防奥沙利铂致周围神经毒性的临床观察  

Clinical Observation of Xinhuang Tablets Mixed with Vinegar on the Prevention of Oxaliplatin-Induced Peripheral Neurotoxicity

作　　者：张丽娜[1] 倪敏[1] 罗林[1] 梁鑫 牛亚琳 肖梦圆 詹雪梅[2] ZHANG Li-na;NI Min;LUO Lin;LIANG Xin;NIU Ya-lin;XIAO Meng-yuan;ZHAN Xue-mei(Department of Traditional Chinese Medicine,First Affi liated Hospital of Anhui Medical University,Hefei Anhui 230022,China;Nursing Department,First Affi liated Hospital of Anhui Medical University,Hefei Anhui 230022,China)

机构地区：[1]安徽医科大学第一附属医院中医科,安徽合肥230022 [2]安徽医科大学第一附属医院护理部,安徽合肥230022

出　　处：《中华养生保健》2025年第2期110-113,共4页CHINESE HEALTH CARE

摘　　要：目的观察新癀片调醋外敷对奥沙利铂化疗所致周围神经毒性的预防作用。方法选取安徽医科大学第一附属医院收治的122例接受奥沙利铂化疗的胃肠恶性肿瘤患者作为研究对象,按随机数表法分为对照组和观察组,每组61例。对照组采用化疗护理常规,干预组在化疗护理常规基础上采用新癀片调醋外敷输液处周围局部皮肤。观察并比较两组周围神经毒性发生率、毒性分级情况、中医证候积分。结果干预前,两组患者周围神经毒性发生率比较,差异无统计学意义(P>0.05);干预后,两组患者周围神经毒性发生率比较,差异有统计学意义(P<0.05)。干预前,两组患者周围神经毒性分级比较,差异无统计学意义(P>0.05);干预后,两组患者周围神经毒性分级比较,差异有统计学意义(P<0.05)。干预前,两组患者的中医证候总分,四肢麻木、手足厥寒、神疲乏力、头晕目眩及屈伸不利维度评分比较,差异无统计学意义(P>0.05);干预后,两组患者的中医证候总分,四肢麻木、手足厥寒、神疲乏力、头晕目眩及屈伸不利维度评分比较,差异有统计学意义(P<0.05)。结论新癀片调醋外敷能降低胃肠恶性肿瘤化疗患者奥沙利铂周围神经毒性发生率,减轻其严重程度,明显改善“寒凝血瘀型”血痹的中医证候,方便易行。Objective To observe the preventive effect of Xinhuang tablets mixed with vinegar on Oxaliplatin-induced peripheral neurotoxicity.Methods A total of 122 patients with gastrointestinal malignancy treated with oxaliplatin chemotherapy admitted to the Department of Traditional Chinese Medicine of a Class III Grade A hospital were randomly divided into two groups:control group(61 cases)and observer group(61 cases).The control group was treated with chemotherapy nursing routine,while the intervention group was treated with Xinhuang Tablet dissolved in vinegar on the local skin around the infusion site on the basis of chemotherapy nursing routine.The incidence of peripheral neurotoxicity,toxicity grade and TCM syndrome score of the two groups were observed.Results Before intervention,there was no significant difference in the incidence of peripheral neurotoxicity between the two groups(P>0.05).After intervention,there was signifi cant difference in the incidence of peripheral neurotoxicity between the two groups(P<0.05).Before intervention,there was no signifi cant difference in the peripheral neurotoxicity grade between the two groups(P>0.05).After intervention,there was signifi cant difference in the peripheral neurotoxicity grade between the two groups after intervention(P<0.05).Before intervention,there was no signifi cant difference in the total score of TCM symptoms,numbness of limbs,cold of hands and feet,mental fatigue,dizziness and adverse fl exion and extension scores between the two groups(P>0.05).After intervention,there were statistically signifi cant differences in the total score of TCM symptoms,numbness of limbs,cold of hands and feet,mental fatigue,dizziness and adverse fl exion and extension scores between the two groups(P<0.05).Conclusion External application of Xinhuang Tablets mixed with vinegar can reduce the incidence of Oxaliplatin-induced peripheral neurotoxicity in patients with gastrointestinal malignant tumor chemotherapy,reduce its severity,and obviously improve the TCM syndrome of"cold coa

关 键 词：新癀片 醋 奥沙利铂 周围神经毒性 血痹 寒凝血瘀型 

分 类 号：R473.73[医药卫生—护理学]