妊娠期女性阴道微生态与B族链球菌感染情况对妊娠结局的影响  

Effect Analysis of Vaginal Microecology and Group B Streptococcus Infection on Pregnancy Outcome of Pregnant Women

作　　者：吕玉贞 冯达记 周子琼 冯米妹 冯梅 LV Yuzhen;FENG Daji;ZHOU Ziqiong;FENG Mimei;FENG Mei(Laboratory Department,Yangjiang City Traditional Chinese Medicine Hospital,Yangjiang,Guangdong 529500;Laboratory Department,Yangdong District People's Hospital,Yangjiang,Guangdong 529500;Obstetrics and Gynecology Department Yangjiang City Traditional Chinese Medicine Hospital,Yangjiang,Guangdong 529500)

机构地区：[1]广东省阳江市中医医院检验科,广东阳江529500 [2]广东省阳江市人民医院检验科,广东阳江529500 [3]广东省阳江市中医医院妇产科,广东阳江529500

出　　处：《智慧健康》2024年第35期29-32,共4页Smart Healthcare

摘　　要：目的探讨妊娠期女性阴道微生态与B族链球菌(GBS)感染情况对妊娠结局的影响。方法将2022年1月—2023年8月本院收治的453例妊娠晚期孕妇纳入研究,并采集所有研究对象阴道侧壁上1/3处肛周分泌物,行阴道分泌物微生物检查,明确受检对象的阴道微生态失衡情况;后续采用细菌培养鉴定,明确受检对象的GBS感染情况。对比微生态平衡组与微生态失衡组在不良妊娠结果及新生儿结局方面的差异;分析GBS阳性组与GBS阴性组在不良妊娠结果及新生儿结局方面的差异。结果本研究所选取的453例妊娠期女性中,阴道微生态失调共160例,阴道微生态正常共293例;GBS检查结果呈阳性者共45例,GBS检查结果呈阴性者共408例。微生态失调组白带常规(阴道清洁度)异常占比高于微生态正常组,GBS阳性组白带常规异常占比明显高于GBS阴性组(P<0.05)。微生态失调组与微生态正常组不良妊娠风险无明显差异(P>0.05)。GBS阳性组新生儿不良结局中低体重发生率较GBS阴性组明显更高(P<0.05)。结论妊娠期女性阴道微生态与GBS感染情况对妊娠结局有一定的负性影响,相较而言GBS感染更易导致新生儿不良结局发生,故需要临床及早进行筛查,制定对应干预方案。Objective To explore the effect of vaginal microbiota and group B Streptococcus(GBS)infection on pregnancy outcomes of pregnant women.Methods The paper chose 453 pregnant women at late stage of pregnancy from January 2022 to August 2023 for study and research analysis,collected anal secretions from 1/3 of vaginal sidewall of study subjects,carried on vaginal secretion microbiological examination to clarify imbalance of vaginal microbiota.Subsequently,GBS infection status of tested subjects was determined with bacterial culture identification.Difference in adverse pregnancy outcomes and neonatal outcomes was compared between the normal microbiota group and dysbiosis microbiota group.Difference in adverse pregnancy outcomes and neonatal outcomes was compared between GBS positive group and GBS negative group.Results Among 453 pregnant women in the study,there were 160 cases of vaginal microbiota imbalance and 293 cases of normal vaginal microbiota,45 cases with positive GBS test results and 408 cases with negative GBS test results.Proportion of abnormal vaginal discharge routine(vaginal cleanliness)in the microecological imbalance group was higher than the microecological normal group,that of abnormal vaginal discharge routine in the GBS positive group was significantly higher than the GBS negative group,(P<0.05).There was no significant difference in adverse pregnancy risk between the microbiota dysbiosis group and the microbiota normal group(P>0.05).Incidence of low body weight of adverse outcomes in the GBS positive group was significantly higher than the GBS negative group(P<0.05).Conclusion Vaginal microbiota and GBS infection of pregnant women has some certain negative effect on pregnancy outcomes.GBS infection is more likely to cause adverse outcomes of newborns,it is necessary to develop early clinical screening and corresponding intervention schemes.

关 键 词：妊娠期女性 阴道微生态 B族链球菌感染 妊娠结局 新生儿结局 

分 类 号：R71[医药卫生—妇产科学]