利多卡因代谢物的法医毒物动力学研究  

Research and Analysis on Forensic Toxicokinetics of Lidocaine Metabolites

作　　者：赵浩然 胡朝奎 ZHAO Haoran;HU Chaokui(Yunnan Yuntong Judicial Appraisal Center,Kunming,Yunnan 655000)

机构地区：[1]云南云通司法鉴定中心,云南昆明655000

出　　处：《智慧健康》2024年第35期70-72,共3页Smart Healthcare

摘　　要：目的研究和分析利多卡因代谢物的法医毒物动力学。方法选择实验动物为犬12只,建立利多卡因与代谢产物的死后分布和死后弥散动物模型,分别应用HPLC检测方法及HPLC-MS/ms检测方法,分析HPLC检测方法利多卡因、地西泮、MEGX高效液相色谱图及选择回收率,检测利多卡因与代谢产物GX及GEX死后弥散情况。结果试验犬完全丧失生命体征时给药后30 min,利多卡因含量自高至低分别为外周血、脑、脾,72 h时利多卡因含量自高至低分别为脑、外周血及脾,未检出GX及MEGX。结论根据能够在脏器组织中检出GX和MEGX可对利多卡因生前染毒或死后染毒进行判断。Objective To study and analyze forensic toxicokinetics of lidocaine metabolites.Methods The paper chose 12 dogs as experimental animals to establish animal models for the postmortem distribution and dispersion of lidocaine and its metabolites,detected with HPLC-MS/ms detection method and HPLC detection method,analyzed lidocaine,diazepam,MEGX high-performance liquid chromatography and selective recovery rate with HPLC detection method,and detected postmortem dispersion of lidocaine and its metabolites GX and GEX.Results Dogs completely lost vital signs 30 min after administration,levels of lidocaine ranged from high to low in peripheral blood,brain and spleen.At 72 hours,levels of lidocaine ranged from high to low in brain,peripheral blood and spleen,and no GX or MEGX was detected.Conclusion Detection of GX and MEGX in organ tissues can be used to determine whether lidocaine was administered before or after death.

关 键 词：利多卡因 代谢物 法医毒物动力学 染毒时间 

分 类 号：R61[医药卫生—外科学]