不同剂量纳布啡超前镇痛预防小儿斜视矫正术后躁动的效果观察  

Effect Observation of Different Doses of Nalbuphine Preemptive Analgesia on Preventing Postoperative Agitation of Children with Strabismus Correction Surgery

作　　者：郑欢洁 叶浩灵 庄沛敏 王萍 ZHENG Huanjie;YE Haoling;ZHUANG Peimin;WANG Ping(Chaozhou People's Hospital,Chaozhou,Guangdong 521000)

机构地区：[1]潮州市人民医院,广东潮州521000

出　　处：《智慧健康》2024年第35期110-112,117,共4页Smart Healthcare

摘　　要：目的探讨不同剂量的纳布啡超前镇痛对预防小儿斜视矫正术后躁动的价值。方法回顾性分析2022年1月—2023年11月本院收治的90例择期行斜视矫正手术的小儿病患的临床资料。按照术后应用纳布啡超前镇痛的药物剂量差异,分成低剂量组(0.1 mg/kg)、中剂量组(0.2 mg/kg)、高剂量组(0.4 mg/kg),每组30例。各组在麻醉诱导前5min予以相关剂量纳布啡快速滴入,后进行麻醉诱导及手术治疗。对比各组患者在麻醉诱导前(T0)、麻醉5 min(T1)、麻醉30 min(T2)、术毕时(T3)的生命体征,各组患者术后不同时间的躁动评分,术后不良反应发生情况。结果三组患儿在T0~T3时刻心率、呼吸频率及血氧饱和度指标,差异均无统计学意义(P>0.05);中、高剂量组的患者在术后30 min、术后1 h、术后2 h的躁动评分均低于低剂量组(P<0.05);低、中剂量组的患者术后不良反应总发生率均低于高剂量组(P<0.05)。结论对于小儿斜视矫正手术患者,应用0.2 mg/kg剂量纳布啡超前镇痛,对术中生命体征无明显影响,并可有效预防术后躁动,且不良反应发生率低。Objective To explore value of different doses of nalbuphine preemptive analgesia in preventing postoperative agitation of children with strabismus correction.Methods The paper chose 90 children with elective strabismus correction surgery,and divided them into low-dose group(0.1mg/kg),medium dose group(0.2 mg/kg)and high-dose group(0.4 mg/kg)based on dose of nalbuphine for preemptive analgesia,with 30 cases in each group.Each group was treated with rapid infusion of relevant doses of nalbuphine 5 minutes before anesthesia induction,followed by anesthesia induction and surgical treatment.Vital signs before anesthesia induction(T0),at 5 minutes of anesthesia(T1),at 30 minutes of anesthesia(T2)and at the end of surgery(T3),agitation scores and incidence of adverse reactions at different times after surgery were compared between groups.Results There was no statistically significant difference in heart rate,respiratory rate and blood oxygen saturation indicators among three groups at T0~T3 time points(P>0.05).The agitation scores of medium and high-dose groups were lower than low-dose group at 30 minutes,1 hour and 2 hours after surgery(P<0.05).Total incidence of postoperative adverse reactions of low and medium dose groups was lower than high-dose group(P<0.05).Conclusion Preemptive analgesia with 0.2 mg/kg dose of nalbuphine has no significant effect on intraoperative vital signs of children with strabismus correction surgery,can prevent postoperative agitation effectively with low incidence of adverse reactions.

关 键 词：小儿斜视 矫正手术 术后躁动 纳布啡 超前镇痛 

分 类 号：R47[医药卫生—护理学]