基于血清学指标分析糖尿病酮症酸中毒的影响因素  

Influencing Factors Analysis of Diabetic Ketoacidosis Based on Serological Indicators

作　　者：庄雯雯[1] ZHUANG Wenwen(Huizhou Central People's Hospital,Huizhou,Guangdong 516001)

机构地区：[1]惠州市中心人民医院,广东惠州516001

出　　处：《智慧健康》2024年第35期113-117,共5页Smart Healthcare

基　　金：惠州市科学技术局课题基金项目《惠州市糖尿病酮症酸中毒危险因素分析联合社区干预研究》(项目编号:2024CZ010255)。

摘　　要：目的基于血清学指标分析糖尿病酮症酸中毒(DKA)的影响因素。方法回顾性分析2022年2月—2024年2月在本院接受治疗的156例DKA患者作为酸中毒组,并选取同期住院且未出现酮症酸中毒的150例糖尿病患者作为对照组。收集患者临床资料,采用Logistic回归分析法分析糖尿病患者发生DKA的影响因素。结果单因素分析结果显示,酸中毒组年龄≥60岁、饮料、甜食经常饮用、血糖控制不良、降糖药物使用中断、胰岛素剂量不足或中断、存在感染患者占比明显高于对照组(P<0.05),酸中毒组患者BMI、糖尿病病程、FBG、HbA1c、BMI、LDL、TG、AMY水平明显高于对照组,C肽水平明显高于对照组(P<0.05)。多因素Logistic回归分析结果显示饮料、甜食、糖尿病病程、降糖药物使用中断、胰岛素剂量不足或中断、存在感染、FBG、HbA1c为糖尿病患者发生DKA的独立危险因素(P<0.05)。结论本研究通过分析血清学指标明确了FBG、HbA1c是糖尿病发生DKA的重要影响因素,此外饮料、甜食、糖尿病病程、降糖药物使用中断、胰岛素剂量不足或中断、存在感染均与糖尿病发生DKA有关,这为DKA的早期诊断和风险评估提供了新的思路和方法。Objective To analyze influencing factors of diabetic ketoacidosis(DKA)based on serological indicators.Methods The paper reviewed and chose 156 DKA patients in our hospital as the acidosis group and 150 diabetes patients without ketoacidosis hospitalized at the same time as the control group from February 2022 to February 2024.Clinical data of patients were collected,influencing factors of DKA patients were analyzed by logistic regression.Results Univariate analysis showed,proportion of patients with acidosis group age≥60,frequent use of beverages and sweets,poor blood glucose control,interruption of hypoglycemic drug use,insufficient or interruption of insulin dose and infection was significantly higher than the control group(P<0.05).Levels of BMI,diabetes course,FBG,HbA1c,BMI,LDL,TG and AMY in the acidosis group were significantly higher than the control group,level of C-peptide was significantly higher than the control group(P<0.05).Multivariate logistic regression analysis showed,drinks,sweets,diabetes course,interruption of hypoglycemic drug use,insufficient or interruption of insulin dose,infection,FBG,HbA1c were independent risk factors of DKA patients(P<0.05).Conclusion By analyzing serological indicators,the study confirms FBG and HbA1c are important influencing factors for occurrence of DKA.In addition,drinks,sweets,diabetes course,interruption of hypoglycemic drugs,insufficient or interruption of insulin dosage and infection are related to occurrence of DKA of diabetes,which provides new ideas and methods for early diagnosis and risk assessment of DKA.

关 键 词：血清学指标 糖尿病酮症酸中毒 影响因素 

分 类 号：R58[医药卫生—内分泌]