血清miR-423-5p、铁蛋白在老年骨质疏松症中表达及与髋部脆性骨折发生的关系  

Expression of serum miR-423-5p and ferritin in elderly osteoporosis and their relationship with hip fragility fracture

作　　者：夏明 李倩[1] 张丽萍 涂艳 XIA Ming;LI Qian;ZHANG Liping;TU Yan(Department of Geriatrics,Liyuan Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430077,China)

机构地区：[1]华中科技大学同济医学院附属梨园医院老年病科,湖北武汉430077

出　　处：《国际检验医学杂志》2025年第4期419-424,共6页International Journal of Laboratory Medicine

基　　金：湖北省中医药科研立项项目(ZY2023M021)。

摘　　要：目的探讨血清微小核糖核酸(miR)-423-5p、铁蛋白在老年骨质疏松症(OP)中表达及与髋部脆性骨折发生的关系。方法选取2020年3月至2024年3月该院收治的老年OP患者79例为观察组,另同期选取在该院有完整体检记录报告的老年体检健康者62例作为对照组。根据是否发生髋部脆性骨折将观察组患者分为骨折组(42例)与未骨折组(37例)。比较观察组与对照组及骨折组与未骨折组患者血清miR-423-5p、铁蛋白水平。比较骨折组与未骨折组患者各部位骨密度(BMD)差异,采用Pearson法分析血清miR-423-5p、铁蛋白与不同部位BMD的相关性,采用受试者工作特征(ROC)曲线分析血清miR-423-5p、铁蛋白对老年髋部脆性骨折的预测价值。结果观察组血清miR-423-5p、铁蛋白高于对照组,差异有统计学意义(P<0.05)。骨折组血清miR-423-5p、铁蛋白水平高于未骨折组,差异有统计学意义(P<0.05)。未骨折组大转子BMD、总髋部BMD高于骨折组,差异有统计学意义(P<0.05)。经Pearson相关分析,老年OP患者血清miR-423-5p、铁蛋白水平与所检测的腰椎、股骨颈、大转子、转子间及总髋部各个部位BMD均呈负相关(P<0.05)。ROC曲线分析结果显示,血清miR-423-5p、铁蛋白联合预测的灵敏度为0.786,特异度为0.892,曲线下面积(AUC)为0.818(95%CI:0.715~0.912),高于二者单独预测的AUC,预测价值更高(P<0.05)。结论血清miR-423-5p、铁蛋白水平联合对老年OP患者髋部脆性骨折发生风险有预测价值。Objective To investigate the expression of serum micro ribonucleic acid(miR)-423-5p and ferritin in elderly osteoporosis(OP)and their relationship with hip fragility fracture.Methods A total of 79 elderly OP patients admitted to the hospital from March 2020 to March 2024 were selected as the observation group,and 62 healthy elderly patients with complete physical examination records and reports were selected as the control group during the same period.Patients in the observation group were divided into fracture group(42 cases)and non-fracture group(37 cases)according to the occurrence of hip fragility fracture.Serum miR-423-5p and ferritin levels were compared between the observation group and the control group and between the fracture group and the non-fracture group.The difference of bone mineral density(BMD)at different sites between the fracture group and the non-fracture group was compared.The correlation between serum miR-423-5p and ferritin and BMD at different sites was analyzed by Pearson,and the predictive value of serum miR-423-5p and ferritin in elderly hip fragility fractures was analyzed by receiver operating characteristic(ROC)curve.Results Serum miR-423-5p and ferritin in observation group were higher than those in control group,the differences were statistically significant(P<0.05).The levels of serum miR-423-5p and ferritin in fracture group were higher than those in non-fracture group,and the differences were statistically significant(P<0.05).Greater trochanteric BMD and total hip BMD in the non-fracture group were higher than those in the fracture group,and the differences were statistically significant(P<0.05).According to Pearson correlation analysis,serum miR-423-5p and ferritin levels in elderly OP patients were negatively correlated with BMD detected in lumbar spine,femoral neck,greater trochanter,intertrochanter and total hip(P<0.05).ROC curve analysis results showed that the sensitivity,specificity and the area under the curve(AUC)of serum miR-423-5p combined with ferritin were 0.786,0.

关 键 词：微小核糖核酸-423-5p 铁蛋白 骨质疏松症 髋部脆性骨折 

分 类 号：R687.3[医药卫生—骨科学]