人工关节耐甲氧西林金黄色葡萄球菌感染的治疗药物临床综合评价  

Clinical Comprehensive Evaluation of MRSA Treatment Drugs in Artificial Joint Infection

作　　者：刘心如 李梦露 龚金红 王禹基 苏丹 周鑫叠 商晶晶 LIU Xinru;LI Menglu;GONG Jinhong;WANG Yuji;SU Dan;ZHOU Xindie;SHANG JingJing(Department of Pharmacy,Changzhou Second People's Hospital Affiliated to Nanjing Medical University,Changzhou 213003,China;School of Pharmacy,Dalian Medical University,Dalian 116000,China;Department of Orthopedics,Changzhou Second People's Hospital Affiliated to Nanjing Medical University,Changzhou 213003,China)

机构地区：[1]南京医科大学附属常州第二人民医院药学部,常州213003 [2]大连医科大学药学院,大连116000 [3]南京医科大学附属常州第二人民医院骨科,常州213003

出　　处：《医药导报》2025年第3期422-428,共7页Herald of Medicine

基　　金：全国肺栓塞与深静脉血栓形成防治能力建设项目(P029);常州市科技局指导性项目(CJ20239022);江苏省药学会奥赛康专项基金资助项目(A202328)。

摘　　要：目的多方位评价人工关节耐甲氧西林金黄色葡萄球菌(MRSA)感染治疗药物综合价值,解决人工关节MRSA感染难题。方法通过文献调研,检索相关文献,筛选归纳出符合要求的临床研究。应用层次分析法,收集临床综合评价证据,以评价指南为准则进行不同维度的评价;运用德尔菲法与层次分析法结合专家匿名问卷评价,对数据进行比对分析。结果成功建立了治疗人工关节感染治疗药物的临床综合评价指标模型,采用yaahp分析软件对各方向的临床综合评价证据进行评分;通过该软件分析权重计算MRSA治疗药物万古霉素、达托霉素及利奈唑胺各级指标的最终临床综合评价权重,得出利奈唑胺临床综合评价得分最高。结论在人工关节MRSA感染的治疗药物中,利奈唑胺临床综合价值更高,可为人工关节MRSA感染的临床治疗提供参考依据。Objective To evaluate the comprehensive value of methicillin-resistant Staphylococcus aureus(MRSA)treatment drugs in artificial joint infections from multiple perspectives and to solve the problem of MRSA infections in artificial joints.Methods Through literature research,relevant literature was retrieved and clinical studies meeting the requirements were selected and summarized.The Analytic Hierarchy Process(AHP)was applied to collect comprehensive clinical evaluation evidence and to conduct evaluations across different dimensions according to evaluation guidelines;the Delphi method combined with AHP was used for expert anonymous questionnaire evaluation,and the data was compared and analyzed.Results A clinical comprehensive evaluation index model for the treatment of artificial joint infections was successfully established,and the yaahp analysis software was used to score the comprehensive clinical evaluation evidence in various directions.Treatment drugs,vancomycin,daptomycin,and linezolid,at various levels were calculated through the software,and it was concluded that linezolid has the highest clinical comprehensive evaluation score.Conclusion Among the treatment drugs for MRSA infections in artificial joints,linezolid has a higher clinical comprehensive value and can provide a reference for the clinical treatment of MRSA infections in artificial joints.

关 键 词：耐甲氧西林金黄色葡萄球菌 人工关节感染 临床综合评价 层次分析法 德尔菲法 

分 类 号：R978.1[医药卫生—药品] R969[医药卫生—药学]