吲哚布芬致脱发与口腔溃疡1例  

A Case of Alopecia and Mouth Ulcers Caused by Indobufen

作　　者：芦红 牟燕[2] 韩毅[2] LU hong;MU yan;HAN yi(Department of Pharmacy,Yucheng People's Hospital,Yucheng 251200,China;Department of Clinical Pharmacy,the First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan Hospital,Shandong Engineering and Technology Research Center for Pediatric Drug Development,Shandong Medicine and Health Key Laboratory of Clinical Pharmacy,Jinan 250014,China)

机构地区：[1]山东省禹城市人民医院药剂科,禹城251200 [2]山东第一医科大学第一附属医院(山东省千佛山医院)临床药学科,山东省儿童药物临床评价与研发工程技术研究中心,山东省医药卫生临床药学重点实验室,济南250014

出　　处：《医药导报》2025年第3期479-480,共2页Herald of Medicine

摘　　要：该文报道1例40岁女性患者因不稳定型心绞痛口服吲哚布芬片0.1 g、bid,瑞舒伐他汀钙片10 mg、qd和沙库巴曲缬沙坦钠片100 mg、qd。1个月后,患者出现严重脱发和多发口腔溃疡。考虑到与吲哚布芬片有关,停用该药,1周内患者症状明显改善。对患者临床资料进行分析,并进行不良反应关联性评价,认为系吲哚布芬导致脱发与口腔溃疡等不良反应。The article reported a case of a 40-year-old female patient with unstable angina who was administered indobufen tablets 0.1 g orally twice a day,rosuvastatin calcium tablets 10 mg once daily,and sacubitril/valsartan sodium tablets 100 mg once daily.After one month,she developed severe alopecia and multiple oral ulcers.Considering the association with indobufen,the drug was discontinued,and the patient's symptoms significantly alleviated within a week.The clinical data of the patient and the association with adverse reactions were analyzed and evaluated.It is believed that indobufen causes adverse reactions such as alopecia and oral ulcers.

关 键 词：吲哚布芬 脱发 口腔溃疡 不良反应 

分 类 号：R971.1[医药卫生—药品] R969[医药卫生—药学]