黄芪精口服液联用华法林致国际标准化比值异常升高1例  

A Case with Abnormally Elevated INR Caused by the Combination of Astragalus Oral Liquid and Warfarin

作　　者：高圆 王燕萍[1] 李波霞[1] GAO yuan;WANG Yanping;LI Boxia(Department of Pharmacy,the First Hospital of Lanzhou University,Lanzhou 730000,China;Department of Pharmacy,People's Hospital of Ningxia Hui Autonomous Region,Ningxia Medical University,Yinchuan750000,China)

机构地区：[1]兰州大学第一医院药剂科,兰州730000 [2]宁夏回族自治区人民医院(宁夏医科大学附属自治区人民医院)药学部,银川750000

出　　处：《医药导报》2025年第3期480-481,共2页Herald of Medicine

摘　　要：1例行主动脉瓣机械瓣置换患者,术后一般状况良好,在药师指导下以华法林(2.25 mg·d^(-1)与3 mg·d^(-1)交替)抗凝,国际标准化比值(INR)1.91出院。出院后除遵医嘱规律服用华法林和其他抗心力衰竭药物外,自行购买黄芪精口服液,服用12 d后反复牙龈出血,INR 4.95。立即停用华法林和黄芪精口服液,3 d后重启华法林抗凝治疗,监测INR并调整剂量,华法林维持剂量3 mg·d^(-1),INR约2.0。考虑患者INR异常升高为华法林与黄芪精口服液相互作用所致。One patient who underwent mechanical aortic valve replacement was in good condition after surgery,and was discharged with warfarin(2.25 mg·d^(-1)and 3 mg·d^(-1)alternatively)and INR 1.91 under the guidance of the pharmacist.After discharge,in addition to taking warfarin and other medication for heart failure treatment,he purchased Huangjing(astragalus)oral liquid at the pharmacy and took it everyday.Twelve days later,he developed recurrent gingival bleeding and INR was 4.95.Warfarin and astragalus oral liquid were stopped immediately,and warfarin was restarted 3 days later.INR was monitored and the dose was adjusted.The maintenance dose of warfarin was 3 mg·d^(-1)and the INR was around 2.0.It was considered that the abnormally elevated INR was caused by the interaction between warfarin and astragalus extract oral solution.

关 键 词：华法林 黄芪精口服液 药品不良反应 药物相互作用 

分 类 号：R286[医药卫生—中药学] R973.2[医药卫生—中医学]