猪牙皂挥发油组分平衡溶解度和油水分配系数的相似性分析  

Similarity analysis of equilibrium solubility and oil-water partition coefficient of volatile oil of Gleditsiae Fructus Abnormalis

作　　者：陈磊 陈晓兰 董娜娜 谢树才 胡娟 邓琴 黄耀磊 范耕齐 CHEN Lei;CHEN Xiaolan;DONG Nana;XIE Shucai;HU Juan;DENG Qin;HUANG Yaolei;FAN Gengqi(Guizhou Engineering Research Center of Processing and Preparation of Traditional Chinese Medicine,National Engineering Research Center of Miao Medicine,School of Pharmacy,Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China;Yuping Hospital of Traditional Chinese Medicine,Tongren 554000,China)

机构地区：[1]贵州中医药大学药学院,国家苗药工程技术研究中心,贵州中药炮制与制剂工程技术研究中心,贵州贵阳550025 [2]玉屏侗族自治县中医院,贵州铜仁554000

出　　处：《贵州科学》2025年第1期17-21,22,共6页Guizhou Science

基　　金：国家自然科学基金地区基金项目(81860705);国家苗药工程技术研究中心能力提升,编号:黔科合中引地[2023]006;贵州省高等学校中药民族药(苗药)新剂型新制剂工程研究中心,合同编号:黔教技[2022]022。

摘　　要：目的:研究猪牙皂挥发油各代表性成分的平衡溶解度和油水分配系数的相似性,为猪牙皂挥发油组分整体水溶性和脂溶性的表征奠定基础。方法:摇瓶法结合HPLC法测定猪牙皂有效组分的溶解性和油水分配系数(Papp),运用向量余弦法(cosine)、欧氏距离系数、格鲁布斯法(Grubbs)评价其相似性。结果:猪牙皂挥发油代表性成分丹皮酚、丁香酚、甲基丁香酚、芳樟醇、茴香脑在不同pH值缓冲液及水中的平衡溶解度和Papp均具有一定的相似性。结论:相似性分析客观地反映了组分内各成分性质的离散程度,可增加组分性质评价的科学性,为中药组分的制剂设计提供依据。We studied the similarity of equilibrium solubility and oil-water partition coefficient of each representative volatile oil component of Gleditsiae Fructus Abnormalis.The solubility and oil-water partition coefficient of the effective components of Gleditsiae Fructus Abnormalis were determined by flask shaking method combined with HPLC.The similarity was evaluated by vector cosine method,Euclidean distance coefficient and Grubbs method.The equilibrium solubility and oil-water partition coefficient of paeonol,eugenol,methyl eugenol,linalool and anethole in buffer solutions with different pH values and water were similar.The similarity analysis objectively reflects the statistical dispersion of the properties of each component,which can improve the scientificity of the component property evaluation,and provides a basis for the preparation design of the components of traditional Chinese medicine.

关 键 词：相似性分析 向量余弦法 欧氏距离系数 格鲁布斯法 猪牙皂挥发油 

分 类 号：R286[医药卫生—中药学]