基于口腔溃疡用药部位的载药系统研究——以金喉健涂膜剂为例  

Research on drug delivery system based on drug application position of oral ulcer:a case study on Jinhoujian Coating Agent

作　　者：邵涵聪 潘亚林 杨艳 张艳焱 徐剑 SHAO Hancong;PAN Yaling;YANG Yan;ZHANG Yanyan;XU Jian(School of Pharmacy,Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China;National Engineering Research Center of Miao Medicine,Guiyang 550025,China;Guizhou Engineering Research Center of Processing and Preparation of Traditional Chinese Medicine,Guiyang 550025,China)

机构地区：[1]贵州中医药大学药学院,贵州贵阳550025 [2]国家苗药工程技术研究中心,贵州贵阳550025 [3]贵州中药炮制与制剂工程技术研究中心,贵州贵阳550025

出　　处：《贵州科学》2025年第1期46-51,共6页Guizhou Science

基　　金：贵州中医药大学大学生创新创业训练计划项目(贵中医大创合字[2022]82号)。

摘　　要：目的:对口腔溃疡用药部位的载药系统进行研究,将贵州民族药金喉健喷雾剂剂型改进为涂膜剂。方法:以性状评价、成膜时间、延展性、柔韧性、黏附时间构成的综合评分为指标,通过响应面试验优选最佳工艺,并对最优处方进行验证及稳定性试验。结果:金喉健涂膜剂的最佳工艺为PVA 178817 g,甘油0.7 g,乙醇浓度65%。所制涂膜剂性状、涂展性良好,成膜时间短,黏附时间长。结论:本研究研制的金喉健涂膜剂处方设计合理,成膜性好,质量稳定均一。剂型优化后更符合制剂需求,延长药物在创面的停留时间,增强药效,保护创面。We studied the drug delivery system based on the drug application position of oral ulcer,and improved the Jinhoujian Spray into a coating agent.With the comprehensive scores of trait evaluation,film-forming time,ductility,flexibility,and adhesion time as the indexes,the optimal process was determined by response surface method,and the optimal prescription was verified and tested for stability.The optimal process for the coating agent was PVA 178817 g,glycerol 0.7 g,and ethanol concentration 65%.The prepared coating agent had good trait and ductility,short film-forming time,and long adhesion time.The coating agent developed in this study was reasonable in prescription design,and had good film-forming property and stable and uniform quality.The optimized coating agent could better meet the demands for the drug,with prolonged adhesion time and enhanced efficacy.

关 键 词：口腔溃疡 涂膜剂 制备工艺 处方筛选 

分 类 号：R29[医药卫生—民族医学]