人绝经期促性腺激素联合枸橼酸氯米芬对多囊卵巢综合征不孕患者排卵情况及性激素水平的影响  

Effects of human menopausal gonadotropin combined with clomifene citrate on ovulation and sex hormone levels in PCOS infertile patients

作　　者：成定菊 张珍安 闵爱 韩建龙 Cheng Ding-ju;Zhang Zhen-an;Min Ai;Han Jian-long(Department of Medicine and Equipment,Ankang Maternal and Child Health Care Hospital,Ankang 725000,China;Department of Gynecology and Obstetrics,Ankang Maternal and Child Health Care Hospital,Ankang 725000,China;Department of Endocrinology,Ankang Central Hospital,Ankang 725000,China)

机构地区：[1]安康市妇幼保健院药械科,安康725000 [2]安康市妇幼保健院妇产科,安康725000 [3]安康市中心医院内分泌科,安康725000

出　　处：《中国药物应用与监测》2025年第1期74-77,共4页Chinese Journal of Drug Application and Monitoring

摘　　要：目的探讨人绝经期促性腺激素(human menopausal gonadotropin,HMG)联合枸橼酸氯米芬对多囊卵巢综合征(polycystic ovary syndrome,PCOS)不孕患者排卵情况以及性激素水平的影响。方法选取2021年3月至2024年3月安康市妇幼保健院收治的PCOS不孕患者102例,随机数字表法均分为观察组和对照组各51例。对照组给予枸橼酸氯米芬治疗,观察组在对照组的基础上联合HMG进行治疗。比较两组患者的排卵情况、性激素水平、妊娠率以及不良反应发生情况。结果治疗后观察组患者卵巢体积[(8.65±2.12)cm^(3)]小于对照组[(28.14±2.53)cm^(3)],窦卵泡数[(7.13±1.64)个]少于对照组[(9.27±1.42)个](t=3.905、7.045,P<0.05),观察组与对照组优势卵泡数[分别为(2.56±0.84)个vs(2.72±0.37)个]比较,差异无统计意义(t=1.214,P>0.05),观察组睾酮(testosterone,T)、黄体生成素(luteinizing hormone,LH)水平[分别为(1.37±0.21)nmol·L^(-1)、(5.32±1.13)U·L^(-1)]低于对照组[分别为(2.19±0.42)nmol·L^(-1)、(7.09±2.17)U·L^(-1)],观察组E_(2)、FSH水平[分别为(149.28±16.54)pmol·L^(-1)、(7.52±1.39)U·L^(-1)]高于对照组[分别为(137.61±15.93)pmol·L^(-1)、(6.35±1.21)U·L^(-1)](t=12.471、5.167、3.629、4.534,P<0.05)。观察组妊娠率(68.63%)高于对照组(41.18%)(t=7.761,P<0.05),不良反应总发生率比较(15.69%vs 17.64%),差异无统计学意义(χ^(2)=0.071,P>0.05)。结论HMG联合枸橼酸氯米芬治疗PCOS不孕患者能有效改善卵巢体积和窦卵泡数量,调节患者性激素水平,提高妊娠率,且安全性良好。Objective To explore the effect of human menopausal gonadotropin(HMG)combined with clomifene citrate on ovulation and sex hormone levels in polycystic ovary syndrome(PCOS)infertile patients.Methods A total of 102 PCOS infertile patients treated in Ankang Maternal and Child Health Care Hospital from March 2021 to March 2024 were selected and divided into observation group and control group by the random number table method,with 51 in each group.The patients in the control group were treated with clomifene citrate and those in the observation group with HMG based on the regimen in the control group.The ovulation status,sex hormone levels,pregnancy rate and adverse reaction incidence were compared between the two groups.Results After treatment,the ovarian volume in the observation group((8.65±2.12)cm^(3))was smaller than that of the control((28.14±2.53)cm^(3)),the antral follicles number((7.13±1.64))was smaller than that of the control((9.27±1.42))(t=3.905,7.045,P<0.05).The comparison of the number of dominant follicles between the observation group and the control group[(2.56±0.84),(2.72±0.37)]showed no significant difference(t=1.214,P>0.05).The T and LH levels of the observation group after treatment(respectively(1.37±0.21)nmol·L^(-1),(5.32±1.13)U·L^(-1))were lower than those of the control(respectively(2.19±0.42)nmol·L^(-1),(7.09±2.17)U·L^(-1)),E_(2) and FSH levels(respectively(149.28±16.54)pmol·L^(-1),(7.52±1.39)U·L^(-1))were higher than those in the control(respectively(137.61±15.93)pmol·L^(-1),(6.35±1.21)U·L^(-1))(t=12.471,5.167,3.629,4.534,P<0.05).The pregnancy rate in the observation group(68.63%)was higher than that in the control(41.18%)(t=7.761,P<0.05).The total incidence was not statistically different between the two groups(15.69%vs 17.64%)(χ^(2)=0.071,P>0.05).Conclusion HMG combined with clomifene citrate in the treatment of PCOS infertile patients can improve the ovarian volume and the number of antral follicles,regulate the levels of sex hormones in patients and increase pregna

关 键 词：人绝经期促性腺激素 枸橼酸氯米芬 多囊卵巢综合征 不孕 排卵 性激素 

分 类 号：R711.75[医药卫生—妇产科学] R711.6[医药卫生—临床医学]