马钱子在骨伤科的应用研究进展  

Research Progress in Applications of Strychnine Semen in Orthopedics and Traumatology

作　　者：于玟路 张虹[2] YU Wenlu;ZHANG Hong(Graduate School of Hunan University of Traditional Chinese Medicine,Changsha Hunan 410208,China;Research Discipline Office of Luoyang Orthopedic Hospital,Luoyang Henan 471002,China)

机构地区：[1]湖南中医药大学研究生院,湖南长沙410208 [2]河南省洛阳正骨医院科研学科办,河南洛阳471002

出　　处：《中国药物警戒》2025年第1期116-120,共5页Chinese Journal of Pharmacovigilance

基　　金：2024年河南省中医药科学研究专项课题(2023ZY3078);2022年河南省中医药科学研究专项课题(2022ZY1137)。

摘　　要：目的探讨马钱子在骨伤科治疗中的安全性和合理用药策略,以确保治疗效果并减少其毒性风险。方法分析马钱子在治疗骨折愈合、骨质增生、骨关节炎、脊髓损伤、颈椎病和腰椎间盘突出等疾病中的应用情况。研究马钱子的剂量控制、用药监测、炮制减毒方法以及与其他药物的配伍禁忌。结果临床应用显示,马钱子在治疗骨折愈合、骨质增生、骨关节炎、脊髓损伤以及颈椎病和腰椎间盘突出等疾病方面表现出较好的疗效。然而,由于其含有的毒性成分,马钱子在临床的安全应用引发学者的进一步研究。结论马钱子含有毒性成分,其临床安全应用需要进一步研究和讨论。通过合理控制剂量、监测用药、炮制减毒和避免不当配伍,可以促进马钱子的安全有效使用。Objective To investigate the safety and rational use of Strychnos Semen in orthopedic treatments in order to ensure therapeutic efficacy while reducing the risk of toxicity.Methods The applications of Strychnos Semen in treating such conditions as fracture healing,osteoarthritis,bone hyperplasia,spinal cord injuries,cervical spondylosis,and lumbar disc herniation were analyzed.The dosage control,medication monitoring,detoxification through processing,and contraindications with other medications were studied.Results Clinical applications demonstrated that Strychnos Semen had shown significant efficacy in treating fracture healing,osteoarthritis,bone hyperplasia,spinal cord injuries,cervical spondylosis,and lumbar disc herniation.However,the presence of toxic components in Strychnos Semen had cast doubt on its safe clinical application.Conclusion Strychnos Semen contains toxic components,so more research on its safe clinical applications is required.The safe and effective use of Strychnos Semen can be facilitated by appropriately controlling dosages,monitoring medication,processing for detoxification,and avoiding improper medication combinations.

关 键 词：马钱子 马钱子碱 骨伤科 临床应用 安全性 合理用药 

分 类 号：R961[医药卫生—药理学]