EB病毒DNA、C反应蛋白、白细胞介素-6、异型淋巴细胞检测对小儿呼吸道EB病毒感染的诊断价值分析  

Analysis of diagnostic value of EB virus DNA,C-reactive protein,interleukin-6 and abnormal lymphocyte for respiratory infection of EB virus in children

作　　者：张晓明 ZHANG Xiao-ming(Yanggu County Hospital of Traditional Chinese Medicine,Liaocheng 252300,China)

机构地区：[1]阳谷县中医医院,252300

出　　处：《中国现代药物应用》2025年第2期55-58,共4页Chinese Journal of Modern Drug Application

摘　　要：目的 分析EB病毒脱氧核糖核酸(EBV-DNA)、C反应蛋白、白细胞介素-6、异型淋巴细胞检测对小儿呼吸道EB病毒感染的诊断价值,以为临床诊断该病提供有益参考。方法 选取呼吸道感染患儿65例纳入研究,均行EBV-DNA、C反应蛋白、白细胞介素-6、异型淋巴细胞检测,以临床病理诊断为金标准,分析不同指标的检测结果,并比较不同检测指标对EB病毒感染的诊断效能(灵敏度、特异度、阴性预测值和阳性预测值)。结果 以临床病理诊断为金标准,65例患儿经检测示54例阳性,11例阴性。EBV-DNA检测示53例阳性,12例阴性;C反应蛋白检测示22例阳性,43例阴性;白细胞介素-6检测示25例阳性,40例阴性;异型淋巴细胞检测示33例阳性,32例阴性。EBV-DNA检测对EB病毒感染的阳性检出率显著高于C反应蛋白、白细胞介素-6、异型淋巴细胞(χ^(2)=30.286、25.128、13.742,P<0.05)。EBV-DNA对EB病毒感染的诊断灵敏度、特异度、准确度、阴性预测值和阳性预测值分别为96.29%、90.91%、95.38%、83.33%、98.11%;C反应蛋白对EB病毒感染的诊断灵敏度、特异度、准确度、阴性预测值和阳性预测值分别为27.78%、36.36%、29.23%、9.30%、68.18%;白细胞介素-6对EB病毒感染的诊断灵敏度、特异度、准确度、阴性预测值和阳性预测值分别为35.18%、45.45%、36.92%、12.50%、76.00%;异型淋巴细胞单项对EB病毒感染的诊断灵敏度、特异度、准确度、阴性预测值和阳性预测值分别为50.00%、45.45%、49.23%、15.63%、81.82%。EBV-DNA对EB病毒感染的诊断灵敏度、特异度、准确度、阴性预测值和阳性预测值显著高于C反应蛋白、白细胞介素-6、异型淋巴细胞(P<0.05)。结论 采用荧光定量聚合酶链反应(PCR)检测呼吸道感染患儿的EBV-DNA能够提高EB病毒感染患儿的检出率,诊断效能很高,可为医师制定治疗方案提供有力依据。Objective To analyze the diagnostic value of EB virus deoxyribonucleic acid(EBV-DNA),C-reactive protein,interleukin-6 and abnormal lymphocyte for respiratory infection of EB virus in children,so as to provide useful reference for clinical diagnosis.Methods A total of 65 children with respiratory infection were selected for study.All the children were tested for EBV-DNA,C-reactive protein,interleukin-6,and abnormal lymphocyte.With clinical pathology as the gold standard,the test results of difference indicators was analyzed,and the diagnostic efficiency(sensitivity,specificity,negative predictive value and positive predictive value) of different indicators for EB virus infection in children were compared.Results Using clinical pathology as the gold standard,54 of 65 children were positive for EB virus and 11 children were negative.EBV-DNA test was positive in 53 cases and negative in 12 cases;C-reactive protein test was positive in 22 cases and negative in 43 cases;interleukin-6 test was positive in 25 cases and negative in 40 cases;abnormal lymphocyte test was positive in33 cases and negative in 32 cases.The positive detection rate of EBV-DNA was significantly higher than that of C-reactive protein,interleukin-6 and abnormal lymphocyte(χ^(2)=30.286,25.128,13.742;P<0.05).The diagnostic sensitivity,specificity,accuracy,negative predictive value and positive predictive value of EBV-DNA for EB virus infection were 96.29%,90.91%,95.38%,83.33% and 98.11%;the diagnostic sensitivity,specificity,accuracy,negative predictive value and positive predictive value of C-reactive protein for EB virus infection were 27.78%,36.36%,29.23%,9.30% and 68.18%;the diagnostic sensitivity,specificity,accuracy,negative predictive value and positive predictive value of interleukin-6 for EB virus infection were 35.18%,45.45%,36.92%,12.50% and76.00%;the diagnostic sensitivity,specificity,accuracy,negative predictive value and positive predictive value of abnormal lymphocyte for EB virus infection were 50.00%,45.45%,49.23%,15.63% and 81.82%.T

关 键 词：EB病毒脱氧核糖核酸 呼吸道感染 荧光定量聚合酶链反应检测 C反应蛋白 白细胞介素-6 异型淋巴细胞 诊断效能 

分 类 号：R725.6[医药卫生—儿科]