艾灸联合滋阴通络方治疗绝经后骨质疏松症临床研究  

Clinical Study on Moxibustion Combined with Ziyin Tongluo Prescription for Postmenopausal Osteoporosis

作　　者：邹爱元[1] 覃海兵[1] 黄英苗[1] 陈荣彬 ZOU Aiyuan;QIN Haibing;HUANG Yingmiao;CHEN Rongbin(Zhuhai Hospital of Guangdong Provincial Hospital of Chinese Medicine,Zhuhai Guangdong 519015,China)

机构地区：[1]广东省中医院珠海医院,广东珠海519015

出　　处：《新中医》2025年第4期101-105,共5页New Chinese Medicine

基　　金：2020年度广东省中医药局面上项目(20200511155351);2021年度珠海市医学科研基金项目(ZH24013310210007PWC)。

摘　　要：目的:观察艾灸联合滋阴通络方治疗绝经后骨质疏松症(PMO)的临床疗效。方法:选择2020年10月—2021年12月在广东省中医院珠海医院治疗的PMO患者110例,按随机数字表法分为对照组与试验组各55例。对照组给予口服阿法骨化醇软胶囊、钙尔奇D片治疗,试验组在对照组基础上给予艾灸联合滋阴通络方治疗。持续治疗3个月,比较2组治疗前后中医证候评分、骨密度、血液流变学指标[纤维蛋白原(Fib)、血沉(ESR)以及红细胞压积(HCT)]、骨形成标志物[血清Ⅰ型前胶原N端前肽(PⅠNP)与碱性磷酸酶(ALP)],同时评价2组的临床疗效及安全性。结果:治疗后,试验组总有效率为96.36%(53/55),对照组为83.64%(46/55),2组比较,差异有统计学意义(P<0.05)。治疗后,2组腰背疼痛、胫痠膝软、神疲肢倦、头晕目眩等中医证候评分均较治疗前降低(P<0.05),且试验组各项评分均低于对照组(P<0.05)。治疗后,2组左侧股骨颈、右侧股骨颈骨及腰椎骨密度均较治疗前升高(P<0.05),且试验组左侧股骨颈、右侧股骨颈骨以及腰椎骨密度均高于对照组(P<0.05)。治疗后,2组PⅠNP、ALP水平均较治疗前升高(P<0.05),且试验组PⅠNP、ALP水平均高于对照组(P<0.05)。治疗后,2组Fib、ESR、HCT水平均较治疗前降低(P<0.05),且试验组Fib、ESR、HCT水平均低于对照组(P<0.05)。治疗期间,2组均未发生肝肾功能异常、胃肠道反应等不良反应。结论:艾灸联合滋阴通络方治疗绝经后骨质疏松症疗效确切,可提高骨密度,促进骨形成,改善患者腰背疼痛症状。Objective:To observe the clinical effect of the therapy of moxibustion combined with Ziyin Tongluo Prescription on postmenopausal osteoporosis(PMO).Methods:A total of 110 PMO patients treated in the Zhuhai Hospital of Guangdong Provincial Hispial of Chinese Medicine from October 2020 to December 2021 were selected and divided into the control group and the trial group by random number table method,with 55 cases in each group.The control group was orally treated with Alfacalcidol Soft Capsules and Caltrate Vitamin D Tablets,and the trial group was additionally treated with moxibustion combined with Ziyin Tongluo Prescription based on the treatment of the control group.After continuous treatment for three months,the traditional Chinese medicine(TCM)syndrome scores,bone mineral density,hemorheological indexes[fibrinogen(Fib),erythrocyte sedimentation rate(ESR)and hematocrit(HCT)]and bone formation markers[serum propeptide of typeⅠprocollagen(PⅠNP)and alkaline phosphatase(ALP)]before and after treatment were compared between the two groups,and the clinical effects and safety in the two groups were evaluated.Results:After treatment,the total effective rate was 96.36%(53/55)in the trial group and 83.64%(46/55)in the control group,the difference being significant(P<0.05).After treatment,the TCM syndrome scores such as back and waist pain,shin soreness and knee weakness,mental fatigue and limbs weakness in the two groups were decreased when compared with those before treatment(P<0.05),and the above scores in the trial group were lower than those in the control group(P<0.05).After treatment,the bone density of left femoral neck,right femoral neck bone and lumbar vertebra in the two groups was increased when compared with that before treatment(P<0.05),and the bone density of left femoral neck,right femoral neck bone and lumbar vertebra in the trial group was higher than that in the control group(P<0.05).After treatment,the levels of PⅠNP and ALP in the two groups were increased when compared with those before treatme

关 键 词：绝经后骨质疏松症 艾灸 滋阴通络方 骨密度 血清Ⅰ型前胶原N端前肽 碱性磷酸酶 

分 类 号：R336[医药卫生—人体生理学]