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作 者:邱雪文 魏华兴 杨华[1] 李丽雯 QIU Xuewen;WEI Huaxing;YANG Hua;LI Liwen(Longyan First Hospital,Longyan 364000,China;不详)
出 处:《中外医学研究》2025年第4期13-16,共4页CHINESE AND FOREIGN MEDICAL RESEARCH
基 金:龙岩市科技计划项目(2022LYF17025)。
摘 要:目的:探究及比较不同剂量维生素D联合深度水解配方粉在轻中度牛奶蛋白过敏(CMPA)中的效果。方法:选取2022年6月—2023年6月龙岩市第一医院收治的100例轻中度CMPA患儿作为研究对象,根据随机数表法分为A组与B组,各50例。两组均应用深度水解配方粉,在此基础上,A组应用400 IU维生素D,B组应用800 IU维生素D,比较两组临床效果、过敏性鼻炎及哮喘确诊情况、治疗前后生长发育指标(体重、身长及头围)、血25-羟维生素D[25(OH)D]及变态反应指标[血清嗜酸性粒细胞趋化因子(Eotaxin)及嗜酸粒细胞阳离子蛋白(ECP)]。结果:B组治疗1周、2周、3周及4周总有效率显著高于A组,过敏性鼻炎、哮喘确诊率显著低于A组,差异有统计学意义(P<0.05)。两组治疗前生长发育指标、血25(OH)D及变态反应指标比较,差异无统计学意义(P>0.05);B组治疗1个月、3个月及6个月后生长发育指标、血25(OH)D显著高于A组,变态反应指标显著低于A组,差异有统计学意义(P<0.05)。结论:深度水解配方粉联合800 IU维生素D在轻中度CMPA中的效果较好,且可有效控制变态反应指标表达。Objective:To explore and compare the effect of different doses of vitamin D combined with deep hydrolysis formula powder in mild to moderate cow's milk protein allergy(CMPA).Method:A total of 100 children with mild to moderate CMPA who treated in Longyan First Hospital from June 2022 and June 2023 were selected as the study objects,they were randomly divided into group A and group B using a random number table method,with 50 cases in each group.Two groups were treated with deep hydrolysis formula powder,on this basis,group A was given 400 IU of Vitamin D,while group B was given 800 IU of Vitamin D,the clinical effect,diagnosis of allergic rhinitis and asthma,growth and development indexes(weight,height and head circumference),blood 25-hydroxyvitamin D[25(OH)D]and allergic reaction indexes[serum eosinophil chemotactic factor(Eotaxin)and eosinophil cationic protein(ECP)]before and after treatment were compared between two groups.Result:The total effective rate of group B patients at 1 week,2 weeks,3 weeks and 4 weeks of treatment were significantly higher than those of group A,and the diagnosis rate of allergic rhinitis and asthma were significantly lower than those of group A,the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in the growth and development indicators,blood 25-(OH)D and allergic reaction indicators between two groups(P>0.05);the growth and development indicators,blood 25-(OH)D in group B after 1 month,3 months and 6 months of treatment were significantly higher than those in group A,and the allergic reaction indicators were significantly lower than those in group A,the differences were statistically significant(P<0.05).Conclusion:Deep hydrolysis formula powder combined with 800 IU Vitamin D has a good effect in mild to moderate CMPA,and can effectively control the expression of allergic reaction indicators.
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